ArticleBeilstein journal of organic chemistry2008
Sordarin, an antifungal agent with a unique mode of action.
Article in Beilstein journal of organic chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Carbamate-Bearing Carbohydrates: Natural Occurrence, Pharmacological Relevance, and Chemical Synthesis.ACS omega · 2026Review
- Uncovering a novel biosynthetic gene cluster for sordarin through genome mining in the fungus Talaromyces adpressus.Bioresources and bioprocessing · 2025Article
- SVC112: From Hummingbirds to Head and Neck Cancer.Advances in experimental medicine and biology · 2025Article
- In Vitro Analysis of the Antagonistic Biological and Chemical Interactions between the EndophyteInternational journal of molecular sciences · 2024Article
- Virulence traits and novel drug delivery strategies for mucormycosis post-COVID-19: a comprehensive review.Frontiers in immunology · 2023Review
- Anti-Infective Antibody-Derived Peptides Active against Endogenous and Exogenous Fungi.Microorganisms · 2021Review
- Cloning and heterologous expression of P450Lent4B11, a novel bacterial P450 gene, for hydroxylation of an antifungal agent sordaricin.The Journal of antibiotics · 2020Article
- Gold(I)-Catalyzed Cycloisomerization of 3-Alkoxyl-1,6-diynes: A Facile Access to Bicyclo[2.2.1]hept-5-en-2-ones.Angewandte Chemie (International ed. in English) · 2020Article
- Genome mining of the sordarin biosynthetic gene cluster from Sordaria araneosa Cain ATCC 36386: characterization of cycloaraneosene synthase and GDP-6-deoxyaltrose transferase.The Journal of antibiotics · 2016Article
- Synthetic Strategies toward Natural Products Containing Contiguous Stereogenic Quaternary Carbon Atoms.Angewandte Chemie (International ed. in English) · 2016Review
- Control of ribosomal subunit rotation by elongation factor G.Science (New York, N.Y.) · 2013Article
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Authors and funding
1 author.
Funding
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Abstract
The sordarin family of compounds, characterized by a unique tetracyclic diterpene core including a norbornene system, inhibits protein synthesis in fungi by stabilizing the ribosome/EF2 complex. This mode of action is in contrast to typical antifungals, which target the cell membrane. This unusual bioactivity makes sordarin a promising candidate for the development of new fungicidal agents, and provided the motivation for extensive research. Three total syntheses (by the Kato, Mander and Narasaka groups), modifications of the glycosyl unit, and changes to the diterpene core (Cuevas and Ciufolini models) will also be discussed in this review.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.