ArticleJournal of immunology (Baltimore, Md. : 1950)2008
MyD88 signaling is not essential for induction of antigen-specific B cell responses but is indispensable for protection against Streptococcus pneumoniae infection following oral vaccination with attenuated Salmonella expressing PspA antigen.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- The Respiratory Commensal BacteriumVaccines · 2023Article
- The Shaping of a B Cell Pool Maximally Responsive to Infections.Annual review of immunology · 2021Article
- Intranasal Vaccination with Outer-Membrane Protein ofImmune network · 2021Article
- IκBζ facilitates protective immunity against Salmonella infection via Th1 differentiation and IgG production.Scientific reports · 2019Article
- Salmonella enterica serovar Choleraesuis vector delivering SaoA antigen confers protection against Streptococcus suis serotypes 2 and 7 in mice and pigs.Veterinary research · 2017Article
- TIR-Domain-Containing Adapter-Inducing Interferon-Journal of clinical & cellular immunology · 2016Article
- A molecular mucosal adjuvant to enhance immunity against pneumococcal infection in the elderly.Immune network · 2015Review
- Mucosal adjuvants for vaccines to control upper respiratory infections in the elderly.Experimental gerontology · 2014Review
- Could a swimming creature inform us on intestinal diseases? Lessons from zebrafish.Inflammatory bowel diseases · 2014Review
- Development ofVaccines · 2014Article
- DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.Nature immunology · 2012Article
- Toll-like receptors are critical for clearance of Brucella and play different roles in development of adaptive immunity following aerosol challenge in mice.Frontiers in cellular and infection microbiology · 2012Article
- Palmitoylation state impacts induction of innate and acquired immunity by the Salmonella enterica serovar typhimurium msbB mutant.Infection and immunity · 2011Article
- Article
- MyD88 signaling is indispensable for primary influenza A virus infection but dispensable for secondary infection.Journal of virology · 2010Article
- Article
- Potential role for mucosally active vaccines against pneumococcal pneumonia.Trends in microbiology · 2010Review
- New technologies in using recombinant attenuated Salmonella vaccine vectors.Critical reviews in immunology · 2010Review
- Selective activation of the p38 MAPK pathway by synthetic monophosphoryl lipid A.The Journal of biological chemistry · 2009Article
- Vaccine-induced antibody isotypes are skewed by impaired CD4 T cell and invariant NKT cell effector responses in MyD88-deficient mice.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
TLRs directly induce innate host defense responses, but the mechanisms of TLR-mediated adaptive immunity remain subject to debate. In this study, we clarified a role of TLR-mediated innate immunity for induction of adaptive immunity by oral vaccination with a live recombinant attenuated Salmonella enteric serovar Typhimurium vaccine (RASV) strain expressing Streptococcus pneumoniae surface protein A (PspA) Ag. Of note, oral or intranasal vaccination with RASV expressing PspA resulted in identical or even significantly higher levels of PspA-specific IgG and IgA responses in the systemic and mucosal compartments of MyD88(-/-) mice of either BALB/c or C57BL/6 background when compared with those of wild-type mice. Although PspA-specific CD4(+) T cell proliferation in the MyD88(-/-) mice was minimal, depletion of CD4(+) T cells abolished PspA-specific IgG and IgA responses in the MyD88(-/-) mice of BALB/c background. Of the greatest interest, MyD88(-/-) mice that possessed high levels of PspA-specific IgG and IgA responses but minimal levels of CD4(+) T cell responses died earlier than nonvaccinated and vaccinated wild-type mice following i.v. or intranasal challenge with virulent S. pneumoniae. Taken together, these results suggest that innate immunity activated by MyD88 signals might not be necessary for Ag-specific Ab induction in both systemic and mucosal sites but is critical for protection following oral vaccination with attenuated Salmonella expressing PspA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.