ReviewJournal of lipid research2009
Transcriptional regulation in bacterial membrane lipid synthesis.
Review in Journal of lipid research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 103 citations in OpenAlex.
- Carbadox, a veterinary growth promoter exhibits anticlostridial activity through induction of oxidative stress in Clostridioides difficile.Gut pathogens · 2026Article
- Long-chain fatty acid homeostasis contributes to survival of uropathogenicJournal of bacteriology · 2026Article
- Functionally distinct core microbes of Tricholoma matsutake revealed by cross-study analysis.Microbiome · 2026Article
- The Perspectives of Combining Antibiotics with Saponins-Herbal Excipients.Molecules (Basel, Switzerland) · 2025Review
- Cyclic Di-AMP Affects Cell Membrane Integrity of Streptococcus pneumoniae.Molecular microbiology · 2025Article
- Article
- Highlighting the potential ofFrontiers in microbiology · 2023Article
- FabT, a Bacterial Transcriptional Repressor That Limits Futile Fatty Acid Biosynthesis.Microbiology and molecular biology reviews : MMBR · 2022Review
- Melatonin inhibits Gram-negative pathogens by targeting citrate synthase.Science China. Life sciences · 2022Article
- Comparative Studies to Uncover Mechanisms of Action ofACS infectious diseases · 2022Article
- Mini Review: Bacterial Membrane Composition and Its Modulation in Response to Stress.Frontiers in molecular biosciences · 2021Review
- Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine.Nature communications · 2020Article
- Effect of amino acids on transcription and translation of key genes in E. coli K and B grown at a steady state in minimal medium.New biotechnology · 2019Article
- The transcriptomic response of Streptococcus pneumoniae following exposure to cigarette smoke extract.Scientific reports · 2018Article
- Article
- Article
- Role of long-chain acyl-CoAs in the regulation of mycolic acid biosynthesis in mycobacteria.Open biology · 2017Article
- A conditional mutant of the fatty acid synthase unveils unexpected cross talks in mycobacterial lipid metabolism.Open biology · 2017Article
- Identification and characterization of preferred DNA-binding sites for the Thermus thermophilus transcriptional regulator FadR.PloS one · 2017Article
- Structural and Functional Characterization of the FadR Regulatory Protein fromFrontiers in cellular and infection microbiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
This review covers the main transcriptional mechanisms that control membrane phospholipid synthesis in bacteria. The fatty acid components are the most energetically expensive modules to produce; thus, the regulation of fatty acid production is very tightly controlled to match the growth rate of cells. Gram-negative and Gram-positive bacteria have evolved different structural classes of regulators to control the genes required for fatty acid biosynthesis. Also, there are other transcriptional regulators that allow the cells to alter the structure of fatty acids in existing phospholipid molecules or to modify the structures of exogenous fatty acids prior to their incorporation into the bilayer. A major thrust for future research in this area is the identification of the ligands or effectors that control the DNA binding activity of the transcriptional regulators of fatty acid biosynthesis. With the exception of malonyl-CoA regulation of FapR from Bacillus subtilis and long-chain acyl-CoA regulation of FadR from Escherichia coli and DesT from Pseudomonas aeruginosa, the identity of these intracellular regulators remains unknown.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.