ArticleThe Plant cell2008
The plant TPX2 protein regulates prospindle assembly before nuclear envelope breakdown.
Article in The Plant cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed.
- The meiotic achilles' heel: vulnerability and resilience under environmental stress.Protoplasma · 2026Review
- Progressive oxygenation of developing leaves directs morphogenesis.Science advances · 2026Article
- Article
- Dawning aurora: TPXL3 activates α-Aurora kinase and regulates mitotic spindle morphogenesis.The Plant cell · 2025Article
- The unconventional TPX2 family protein TPXL3 regulates α Aurora kinase function in spindle morphogenesis in Arabidopsis.The Plant cell · 2025Article
- Factor of DNA methylation 1 affects woodland strawberry plant stature and organ size via DNA methylation.Plant physiology · 2023Article
- Heat stress during male meiosis impairs cytoskeletal organization, spindle assembly and tapetum degeneration in wheat.Frontiers in plant science · 2023Article
- Genome-wide analysis ofFrontiers in plant science · 2023Article
- Genome editing of SlMYB3R3, a cell cycle transcription factor gene of tomato, induces elongated fruit shape.Journal of experimental botany · 2022Article
- Comparison of meiotic transcriptomes of three maize inbreds with different origins reveals differences in cell cycle and recombination.BMC genomics · 2022Article
- How Microtubules Build the Spindle Branch by Branch.Annual review of cell and developmental biology · 2022Review
- Spindle motility skews division site determination during asymmetric cell division in Physcomitrella.Nature communications · 2022Article
- Frequent Spindle Assembly Errors Require Structural Rearrangement to Complete Meiosis inInternational journal of molecular sciences · 2022Article
- Biochemical, biophysical, and functional characterisation of the E3 ubiquitin ligase APC/C regulator CDC20 fromFrontiers in physiology · 2022Article
- Transcriptomic Analysis of Radish (Plants (Basel, Switzerland) · 2021Article
- Transcriptome Analyses Throughout Chili Pepper Fruit Development Reveal Novel Insights into the Domestication Process.Plants (Basel, Switzerland) · 2021Article
- A guide to plant TPX2-like and WAVE-DAMPENED2-like proteins.Journal of experimental botany · 2021Article
- Comparative Inter- and IntraSpecies Transcriptomics Revealed Key Differential Pathways Associated With Aluminium Stress Tolerance in Lentil.Frontiers in plant science · 2021Article
- Functional Divergence of Microtubule-Associated TPX2 Family Members inInternational journal of molecular sciences · 2020Article
- Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Targeting Protein for Xklp2 (TPX2) is a central regulator of spindle assembly in vertebrate cells. The absence or excess of TPX2 inhibits spindle formation. We have defined a TPX2 signature motif that is present once in vertebrate sequences but twice in plants. Plant TPX2 is predominantly nuclear during interphase and is actively exported before nuclear envelope breakdown to initiate prospindle assembly. It localizes to the spindle microtubules but not to the interdigitating polar microtubules during anaphase or to the phragmoplast as it is rapidly degraded during telophase. We characterized the Arabidopsis thaliana TPX2-targeting domains and show that the protein is able to rescue microtubule assembly in TPX2-depleted Xenopus laevis egg extracts. Injection of antibodies to TPX2 into living plant cells inhibits the onset of mitosis. These results demonstrate that plant TPX2 already functions before nuclear envelope breakdown. Thus, plants have adapted nuclear-cytoplasmic shuttling of TPX2 to maintain proper spindle assembly without centrosomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.