ArticleProceedings of the National Academy of Sciences of the United States of America2008
Evolutionary redefinition of immunoglobulin light chain isotypes in tetrapods using molecular markers.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 65 citations in OpenAlex.
- Cloning, expression and characterisation of antigen-specific recombinant bat immunoglobulin from the black flying fox (Frontiers in immunology · 2026Article
- Immunoglobulin genetics of a model squamate reptile, Tiliqua rugosa.Immunogenetics · 2025Article
- The genome of the Australian water dragon (Intellagama lesueurii), an agamid model for urban adaptation.The Journal of heredity · 2025Article
- Identification of novel human IgE-binding peptides from a phage display library for total IgE detection.Scientific reports · 2025Article
- Bat humoral immunity and its role in viral pathogenesis, transmission, and zoonosis.Frontiers in immunology · 2024Review
- Characterization of immunoglobulinFrontiers in immunology · 2023Article
- Soluble Papain to Digest Monoclonal Antibodies; Time and Cost-Effective Method to Obtain Fab Fragment.Bioengineering (Basel, Switzerland) · 2022Article
- Individual B cells transcribe multiple rearranged immunoglobulin light chains in teleost fish.iScience · 2021Article
- Molecular Drivers of Lymphocyte Organization in Vertebrate Mucosal Surfaces: Revisiting the TNF Superfamily Hypothesis.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Immunoglobulin Light Chain Gene Rearrangements, Receptor Editing and the Development of a Self-Tolerant Antibody Repertoire.Frontiers in immunology · 2018Review
- Structural reconstruction of protein ancestry.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Immunoglobulin light chain (IGL) genes in torafugu: Genomic organization and identification of a third teleost IGL isotype.Scientific reports · 2017Article
- Identification of secreted and membrane-bound bat immunoglobulin using a Microchiropteran-specific mouse monoclonal antibody.Developmental and comparative immunology · 2016Article
- Characterization of Lamprey BAFF-like Gene: Evolutionary Implications.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Article
- Significant Differences in Physicochemical Properties of Human Immunoglobulin Kappa and Lambda CDR3 Regions.Frontiers in immunology · 2016Article
- Evolution of two prototypic T cell lineages.Cellular immunology · 2015Article
- RNA-Seq analysis and gene discovery of Andrias davidianus using Illumina short read sequencing.PloS one · 2015Article
- The immunoglobulins of cold-blooded vertebrates.Biomolecules · 2014Review
- Genomic donor cassette sharing during VLRA and VLRC assembly in jawless vertebrates.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The phylogenetic relationships of Ig light chain (IGL) genes are difficult to resolve, because these genes are short and evolve relatively fast. Here, we classify the IGL sequences from 12 tetrapod species into three distinct groups (kappa, lambda, and sigma isotypes) using conserved amino acid residues, recombination signal sequences, and genomic organization of IGL genes as cladistic markers. From the distribution of the markers we conclude that the earliest extant tetrapods, the amphibians, possess three IGL isotypes: kappa, lambda, and sigma. Of these, two (kappa and lambda) are also found in reptiles and some mammals. The lambda isotype is found in all tetrapods tested to date, whereas the kappa isotype seems to have been lost at least in some birds and in the microbat. Conservation of the cladistic molecular markers suggests that they are associated with functional specialization of the three IGL isotypes. The genomic maps of IGL loci reveal multiple gene rearrangements that occurred in the evolution of tetrapod species. These rearrangements have resulted in interspecific variation of the genomic lengths of the IGL loci and the number and order of IGL constituent genes, but the overall organization of the IGL loci has not changed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.