ArticleProceedings of the National Academy of Sciences of the United States of America2008
Role of HAMP domains in chemotaxis signaling by bacterial chemoreceptors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 81 citations in OpenAlex.
- Signaling mechanism of the transmembrane energy receptor Aer.bioRxiv : the preprint server for biology · 2026Article
- Protein-protein interfaces in chemotaxis receptor complexes and their role in signaling.FEMS microbiology reviews · 2026Review
- Navigating bacterial motility through chemotaxis: from molecular mechanisms to physiological perspectives.Folia microbiologica · 2025Review
- Chemotaxis and Related Signaling Systems inBiomolecules · 2025Review
- Recent structural advances in bacterial chemotaxis signalling.Current opinion in structural biology · 2023Review
- Mechanisms of E. coli chemotaxis signaling pathways visualized using cryoET and computational approaches.Biochemical Society transactions · 2022Review
- Studying bacterial chemosensory array with CryoEM.Biochemical Society transactions · 2021Review
- Multistep Signaling in Nature: A Close-Up ofInternational journal of molecular sciences · 2021Review
- Article
- Structure and function of the juxtamembrane GAF domain of potassium biosensor KdpD.Protein science : a publication of the Protein Society · 2020Article
- Sequential modification of bacterial chemoreceptors is key for achieving both accurate adaptation and high gain.Nature communications · 2020Article
- Universal Molecular Triggers of Stress Responses in CyanobacteriumLife (Basel, Switzerland) · 2019Review
- Propulsion and Chemotaxis in Bacteria-Driven Microswimmers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2017Article
- Information processing in bacteria: memory, computation, and statistical physics: a key issues review.Reports on progress in physics. Physical Society (Great Britain) · 2016Review
- A new view into prokaryotic cell biology from electron cryotomography.Nature reviews. Microbiology · 2016Review
- Hypothetical Protein BB0569 Is Essential for Chemotaxis of the Lyme Disease Spirochete Borrelia burgdorferi.Journal of bacteriology · 2015Article
- Signaling and Adaptation Modulate the Dynamics of the Photosensoric Complex of Natronomonas pharaonis.PLoS computational biology · 2015Article
- Chemotactic Signaling by Single-Chain Chemoreceptors.PloS one · 2015Article
- New insights into bacterial chemoreceptor array structure and assembly from electron cryotomography.Biochemistry · 2014Article
- Cryo-electron tomography: the challenge of doing structural biology in situ.The Journal of cell biology · 2013Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Bacterial chemoreceptors undergo conformational changes in response to variations in the concentration of extracellular ligands. These changes in chemoreceptor structure initiate a series of signaling events that ultimately result in regulation of rotation of the flagellar motor. Here we have used cryo-electron tomography combined with 3D averaging to determine the in situ structure of chemoreceptor assemblies in Escherichia coli cells that have been engineered to overproduce the serine chemoreceptor Tsr. We demonstrate that chemoreceptors are organized as trimers of receptor dimers and display two distinct conformations that differ principally in arrangement of the HAMP domains within each trimer. Ligand binding and methylation alter the distribution of chemoreceptors between the two conformations, with serine binding favoring the "expanded" conformation and chemoreceptor methylation favoring the "compact" conformation. The distinct positions of chemoreceptor HAMP domains within the context of a trimeric unit are thus likely to represent important aspects of chemoreceptor structural changes relevant to chemotaxis signaling. Based on these results, we propose that the compact and expanded conformations represent the "kinase-on" and "kinase-off" states of chemoreceptor trimers, respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.