ArticleThe Journal of biological chemistry2008
Yin Yang 1 is a critical repressor of matrix metalloproteinase-9 expression in brain neurons.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- The possible pathogenic mechanisms of microorganisms in infertility: a narrative review.Archives of microbiology · 2025Review
- Article
- Fallopian tubal infertility: the result of Chlamydia trachomatis-induced fallopian tubal fibrosis.Molecular and cellular biochemistry · 2022Review
- Yy1 regulates Senp1 contributing to AMPA receptor GluR1 expression following neuronal depolarization.Journal of biomedical science · 2019Article
- The Two Sides of YY1 in Cancer: A Friend and a Foe.Frontiers in oncology · 2019Review
- HuR (Elavl1) and HuB (Elavl2) Stabilize Matrix Metalloproteinase-9 mRNA During Seizure-Induced Mmp-9 Expression in Neurons.Frontiers in neuroscience · 2018Article
- The Novel HDAC8 Inhibitor WK2-16 Attenuates Lipopolysaccharide-Activated Matrix Metalloproteinase-9 Expression in Human Monocytic Cells and Improves Hypercytokinemia In Vivo.International journal of molecular sciences · 2017Article
- The YY1/MMP2 axis promotes trophoblast invasion at the maternal-fetal interface.The Journal of pathology · 2016Article
- Epigenetics of Epileptogenesis-Evoked Upregulation of Matrix Metalloproteinase-9 in Hippocampus.PloS one · 2016Article
- Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo.The EMBO journal · 2015Article
- Activity dependent CAM cleavage and neurotransmission.Frontiers in cellular neuroscience · 2015Review
- Transcriptional Response of Polycomb Group Genes to Status Epilepticus in Mice is Modified by Prior Exposure to Epileptic Preconditioning.Frontiers in neurology · 2015Article
- Article
- Matrix metalloproteinase-9 involvement in the structural plasticity of dendritic spines.Frontiers in neuroanatomy · 2014Review
- Brain-derived neurotrophic factor induces matrix metalloproteinase 9 expression in neurons via the serum response factor/c-Fos pathway.Molecular and cellular biology · 2013Article
- Cyr61, a matricellular protein, is needed for dendritic arborization of hippocampal neurons.The Journal of biological chemistry · 2013Article
- Novel higher-order epigenetic regulation of the Bdnf gene upon seizures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Yin Yang 1 intronic binding sequences and splicing elicit intron-mediated enhancement of ubiquitin C gene expression.PloS one · 2013Article
- Synaptic circuit remodelling by matrix metalloproteinases in health and disease.Nature reviews. Neuroscience · 2012Review
- Mechanisms of Amyloid-β Peptide Clearance: Potential Therapeutic Targets for Alzheimer's Disease.Biomolecules & therapeutics · 2012Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Membrane depolarization controls long lasting adaptive neuronal changes in brain physiology and pathology. Such responses are believed to be gene expression-dependent. Notably, however, only a couple of gene repressors active in nondepolarized neurons have been described. In this study, we show that in the unstimulated rat hippocampus in vivo, as well as in the nondepolarized brain neurons in primary culture, the transcriptional regulator Yin Yang 1 (YY1) is bound to the proximal Mmp-9 promoter and strongly represses Mmp-9 transcription. Furthermore, we demonstrate that monoubiquitinated and CtBP1 (C-terminal binding protein 1)-bound YY1 regulates Mmp-9 mRNA synthesis in rat brain neurons controlling its transcription apparently via HDAC3-dependent histone deacetylation. In conclusion, our data suggest that YY1 exerts, via epigenetic mechanisms, a control over neuronal expression of MMP-9. Because MMP-9 has recently been shown to play a pivotal role in physiological and pathological neuronal plasticity, YY1 may be implicated in these phenomena as well.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.