ReviewThe Journal of biological chemistry2009
Models of spatially restricted biochemical reaction systems.
Review in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Delineation of signaling microdomains from live-cell movies.Cell systems · 2026Article
- High turnover and rescue effect of XRCC1 in response to heavy charged particle radiation.Biophysical journal · 2022Article
- Stable continual learning through structured multiscale plasticity manifolds.Current opinion in neurobiology · 2021Review
- Robust emergence of sharply tuned place-cell responses in hippocampal neurons with structural and biophysical heterogeneities.Brain structure & function · 2020Article
- Degeneracy in hippocampal physiology and plasticity.Hippocampus · 2019Review
- Stores, Channels, Glue, and Trees: Active Glial and Active Dendritic Physiology.Molecular neurobiology · 2019Review
- Luminescence-activated nucleotide cyclase regulates spatial and temporal cAMP synthesis.The Journal of biological chemistry · 2019Article
- Active dendrites regulate the spatiotemporal spread of signaling microdomains.PLoS computational biology · 2018Article
- Mathematical modeling of gonadotropin-releasing hormone signaling.Molecular and cellular endocrinology · 2017Review
- Membrane potential and Ca2+ concentration dependence on pressure and vasoactive agents in arterial smooth muscle: A model.The Journal of general physiology · 2015Article
- Cross talk between CD3 and CD28 is spatially modulated by protein lateral mobility.Molecular and cellular biology · 2014Article
- Dendritic atrophy constricts functional maps in resonance and impedance properties of hippocampal model neurons.Frontiers in cellular neuroscience · 2014Article
- Quantitative interactions between the A-type K+ current and inositol trisphosphate receptors regulate intraneuronal Ca2+ waves and synaptic plasticity.The Journal of physiology · 2013Article
- Exploiting mathematical models to illuminate electrophysiological variability between individuals.The Journal of physiology · 2012Review
- Signaling network prediction by the Ontology Fingerprint enhanced Bayesian network.BMC systems biology · 2012Article
- Developing models in virtual cell.Science signaling · 2011Article
- Cytosolic H+ microdomain developed around AE1 during AE1-mediated Cl-/HCO3- exchange.The Journal of physiology · 2011Article
- Reporting from the field: genetically encoded fluorescent reporters uncover signaling dynamics in living biological systems.Annual review of biochemistry · 2011Review
- Signalling ballet in space and time.Nature reviews. Molecular cell biology · 2010Review
- A new multicompartmental reaction-diffusion modeling method links transient membrane attachment of E. coli MinE to E-ring formation.Systems and synthetic biology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Many reactions within the cell occur only in specific intracellular regions. Such local reaction networks give rise to microdomains of activated signaling components. The dynamics of microdomains can be visualized by live cell imaging. Computational models using partial differential equations provide mechanistic insights into the interacting factors that control microdomain dynamics. The mathematical models show that, for membrane-initiated signaling, the ratio of the surface area of the plasma membrane to the volume of the cytoplasm, the topology of the signaling network, the negative regulators, and kinetic properties of key components together define microdomain dynamics. Thus, patterns of locally restricted signaling reaction systems can be considered an emergent property of the cell.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.