ArticleGenetics2008
Drosophila myt1 is the major cdk1 inhibitory kinase for wing imaginal disc development.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Parallel shifts in differential gene expression reveal convergent miniaturization in fishes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Coordination between cell proliferation and apoptosis after DNA damage in Drosophila.Cell death and differentiation · 2022Article
- Regulation and coordination of the different DNA damage responses inFrontiers in cell and developmental biology · 2022Review
- The miRNALife science alliance · 2019Article
- Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors.Journal of medicinal chemistry · 2017Article
- Prolonged mitotic arrest induced by Wee1 inhibition sensitizes breast cancer cells to paclitaxel.Oncotarget · 2017Article
- Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning.Development (Cambridge, England) · 2016Article
- Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and premeiotic centriole engagement in Drosophila spermatocytes.Molecular biology of the cell · 2016Article
- Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells.Cell reports · 2015Article
- Control of vein network topology by auxin transport.BMC biology · 2015Article
- Mitochondrial Fragmentation Due to Inhibition of Fusion Increases Cyclin B through Mitochondrial Superoxide Radicals.PloS one · 2015Article
- Article
- Dual phosphorylation of cdk1 coordinates cell proliferation with key developmental processes in Drosophila.Genetics · 2014Article
- Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Transcriptional networks controlling the cell cycle.G3 (Bethesda, Md.) · 2013Article
- A genome-wide RNAi screen identifies core components of the G₂-M DNA damage checkpoint.Science signaling · 2011Article
- microRNAs regulate human embryonic stem cell division.Cell cycle (Georgetown, Tex.) · 2009Article
- Tyrosines in the kinesin-5 head domain are necessary for phosphorylation by Wee1 and for mitotic spindle integrity.Current biology : CB · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitosis is triggered by activation of Cdk1, a cyclin-dependent kinase. Conserved checkpoint mechanisms normally inhibit Cdk1 by inhibitory phosphorylation during interphase, ensuring that DNA replication and repair is completed before cells begin mitosis. In metazoans, this regulatory mechanism is also used to coordinate cell division with critical developmental processes, such as cell invagination. Two types of Cdk1 inhibitory kinases have been found in metazoans. They differ in subcellular localization and Cdk1 target-site specificity: one (Wee1) being nuclear and the other (Myt1), membrane-associated and cytoplasmic. Drosophila has one representative of each: dMyt1 and dWee1. Although dWee1 and dMyt1 are not essential for zygotic viability, loss of both resulted in synthetic lethality, indicating that they are partially functionally redundant. Bristle defects in myt1 mutant adult flies prompted a phenotypic analysis that revealed cell-cycle defects, ectopic apoptosis, and abnormal responses to ionizing radiation in the myt1 mutant imaginal wing discs that give rise to these mechanosensory organs. Cdk1 inhibitory phosphorylation was also aberrant in these myt1 mutant imaginal wing discs, indicating that dMyt1 serves Cdk1 regulatory functions that are important both for normal cell-cycle progression and for coordinating mitosis with critical developmental processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.