ArticleNeuron2008
An animal model of a behavioral intervention for depression.
Article in Neuron, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
101 citing papers in PubMed, 1 synthesis or guideline pooled it, 165 citations in OpenAlex.
- Ablating adult neurogenesis in the rat has no effect on spatial processing: evidence from a novel pharmacogenetic model.PLoS genetics · 2013Pooled it
- Auditory associative learning drives synaptic responses in tail of the striatum spiny projection neurons.iScience · 2026Article
- Development and validation of the lifetime sense of safety scale in Kenyan adults.Communications medicine · 2026Article
- Manic switching from depression is affected by adult hippocampal neurogenesis.Animal cells and systems · 2026Article
- Safety learning induces postsynaptic potentiation of direct pathway spiny projection neurons in the tail of the striatum.bioRxiv : the preprint server for biology · 2025Article
- Mothering matters: Towards a better understanding of disrupted infant-caregiver relationships in both mother and offspring.Neurobiology of stress · 2025Review
- Behavioral and Cognitive Comorbidities in Genetic Rat Models of Absence Epilepsy (Focusing on GAERS and WAG/Rij Rats).Biomedicines · 2024Review
- Auditory stimuli suppress contextual fear responses in safety learning independent of a possible safety meaning.Frontiers in behavioral neuroscience · 2024Article
- Early-life iron deficiency persistently disrupts affective behaviour in mice.Annals of medicine · 2023Article
- Nucleus accumbens D1/D2 circuits control opioid withdrawal symptoms in mice.The Journal of clinical investigation · 2023Article
- Ventral Hippocampal Input to Infralimbic Cortex Is Necessary for the Therapeutic-Like Effects of Extinction in Stressed Rats.The international journal of neuropsychopharmacology · 2023Article
- Article
- The metabolic regulator USF-1 is involved in the control of affective behaviour in mice.Translational psychiatry · 2022Article
- Adjunct treatment with ketamine enhances the therapeutic effects of extinction learning after chronic unpredictable stress.Neurobiology of stress · 2022Article
- A Baldwin interpretation of adult hippocampal neurogenesis: from functional relevance to physiopathology.Molecular psychiatry · 2022Review
- Integrative Model of Human-Animal Interactions: A One Health-One Welfare Systemic Approach to Studying HAI.Frontiers in veterinary science · 2022Article
- Race-Dependent Association of Single-Nucleotide Polymorphisms in TrkB Receptor in People Living with HIV and Depression.Neurotoxicity research · 2021Article
- Environmental certainty influences the neural systems regulating responses to threat and stress.Neuroscience and biobehavioral reviews · 2021Review
- Psychosocial impairment following mild blast-induced traumatic brain injury in rats.Behavioural brain research · 2021Article
- Early-life trauma endophenotypes and brain circuit-gene expression relationships in functional neurological (conversion) disorder.Molecular psychiatry · 2021Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Although conditioned inhibition of fear (or learned safety) is a learning process critical for preventing chronic stress, a predisposing factor for depression and other psychopathologies, little is known about its functional purposes or molecular mechanisms. To obtain better insight into learned safety, we investigated its behavioral and molecular characteristics and found that it acts as a behavioral antidepressant in two animal models. Learned safety promotes the survival of newborn cells in the dentate gyrus of the hippocampus, while its antidepressant effect is abolished in mice with ablated hippocampal neurogenesis. Learned safety also increases the expression of BDNF in the hippocampus and leads to downregulation of genes involved in the dopaminergic and neuropeptidergic but not the serotonergic system in the basolateral amygdala. These data suggest that learned safety is an animal model of a behavioral antidepressant that shares some neuronal hallmarks of pharmacological antidepressants but is mediated by different molecular pathways.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.