ArticleBMC physiology2008
Blood pressures, heart rate and locomotor activity during salt loading and angiotensin II infusion in protease-activated receptor 2 (PAR2) knockout mice.
Article in BMC physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Characterization and Functions of Protease-Activated Receptor 2 in Obesity, Diabetes, and Metabolic Syndrome: A Systematic Review.BioMed research international · 2016Pooled it
- Proteinase-Activated Receptor 2 (PAR2) Deficiency and Cardiovascular Regulation: Context-Dependent Effects on Inflammation and Fibrosis.Current issues in molecular biology · 2026Review
- PAR2 Regulates Cardiac Pressure and Vascular Function Through Context-Dependent Signalling Mechanisms.Current issues in molecular biology · 2026Article
- Protease-activated receptors in vascular smooth muscle cells: a bridge between thrombo-inflammation and vascular remodelling.Cell communication and signaling : CCS · 2025Review
- Article
- Cardioprotection by direct factor Xa inhibition in angiotensin II overexpression.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Gastrin stimulates renal dopamine production by increasing the renal tubular uptake of l-DOPA.American journal of physiology. Endocrinology and metabolism · 2017Article
- Small caliber arterial endothelial cells calcium signals elicited by PAR2 are preserved from endothelial dysfunction.Pharmacology research & perspectives · 2015Article
- Article
- Suppression of peripheral sympathetic activity underlies protease-activated receptor 2-mediated hypotension.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2014Article
- Tissue factor, protease activated receptors and pathologic heart remodelling.Thrombosis and haemostasis · 2014Review
- Infant locomotive development and its association with adult blood pressure.European journal of pediatrics · 2014Article
- Targeting proteinase-activated receptors: therapeutic potential and challenges.Nature reviews. Drug discovery · 2012Review
- Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice.BMC pharmacology · 2011Article
- Sex chromosome effects unmasked in angiotensin II-induced hypertension.Hypertension (Dallas, Tex. : 1979) · 2010Article
- Renal dopaminergic defect in C57Bl/6J mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIn this study we used radiotelemetry to measure hemodynamic variables and locomotor activity in conscious unrestrained male Protease-Activated Receptor 2 (PAR-2) knockout mice in order to provide a detailed assessment of their blood pressure phenotype. In addition we tested for an influence of PAR-2 on salt-sensitivity (8% versus 0.5% NaCl diet, 2.5 weeks) and angiotensin II-induced hypertension (1 microg Ile5-angiotensin II/kg/min versus 0.25 microl/h saline, 2 weeks).
resultsSystolic arterial pressures of PAR-2 -/- (129 +/- 1 mmHg, n = 21, P < 0.05) were statistically higher than those of C57BL/6J (124 +/- 1 mmHg, n = 33) throughout the 24 h period under baseline conditions. Pulse pressures in PAR-2 -/- were also significantly elevated (33 +/- 1 mmHg versus 30 +/- 1 mmHg, P < 0.05), whereas diastolic arterial pressures were not. Heart rates in PAR-2 -/- were not significantly different than controls, with the exception that heart rate of PAR-2 -/- was 23 beats per min higher than controls (P < 0.001) during periods of nocturnal activity. The diurnal pattern and intensity of locomotor activity were not found to differ between strains. A high salt diet led to increased blood pressures, decreased heart rates, increased time spent active and decreased intensity levels of locomotor activity. Salt-induced changes in systolic and pulse pressures in PAR-2 -/- were less than in C57B/6J. Angiotensin II treatment increased pressures, decreased heart rates, decreased time spent active and decreased intensity levels of activity of PAR-2 -/-, all to the same extent as C57BL/6J. A trend of lower blood pressures during the middle period of angiotensin II treatment period was observed in individual PAR-2 -/-.
conclusionThe data indicated gene knockout of PAR-2 was associated with a modest change in blood pressure phenotype. PAR-2 -/- mice exhibited moderate elevation of systolic arterial and pulse pressures, yet no increased diastolic arterial pressure, no increased blood pressure responses to high salt diet and a subtle difference in the time course of the blood pressure responses to angiotensin II infusion.
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