ArticleEnvironmental health : a global access science source2008
Spatial variations in the incidence of breast cancer and potential risks associated with soil dioxin contamination in Midland, Saginaw, and Bay Counties, Michigan, USA.
Article in Environmental health : a global access science source, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed.
- A novel method for measuring the burden of breast cancer in neighborhoods.Preventive medicine reports · 2023Article
- Residential proximity to dioxin emissions and risk of breast cancer in the sister study cohort.Environmental research · 2023Article
- Article
- The impact of left truncation of exposure in environmental case-control studies: evidence from breast cancer risk associated with airborne dioxin.European journal of epidemiology · 2022Article
- Chronic Low-Dose Exposure to Xenoestrogen Ambient Air Pollutants and Breast Cancer Risk: XENAIR Protocol for a Case-Control Study Nested Within the French E3N Cohort.JMIR research protocols · 2020Article
- Dioxin exposure and breast cancer risk in a prospective cohort study.Environmental research · 2020Article
- Breast cancer in the Baixada Santista region and its relationship to contaminated areas.Environmental science and pollution research international · 2020Article
- Spatiotemporal patterns of childhood asthma hospitalization and utilization in Memphis Metropolitan Area from 2005 to 2015.The Journal of asthma : official journal of the Association for the Care of Asthma · 2017Article
- Epidemiological and etiological characteristics of hand, foot, and mouth disease in Henan, China, 2008-2013.Scientific reports · 2015Article
- Surveillance of febrile patients in a district and evaluation of their spatiotemporal associations: a pilot study.BMC public health · 2010Article
- Cancer incidence in the population exposed to dioxin after the "Seveso accident": twenty years of follow-up.Environmental health : a global access science source · 2009Article
- A critical assessment of geographic clusters of breast and lung cancer incidences among residents living near the Tittabawassee and Saginaw Rivers, Michigan, USA.Journal of environmental and public health · 2009Article
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2 authors.
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Abstract
backgroundHigh levels of dioxins in soil and higher-than-average body burdens of dioxins in local residents have been found in the city of Midland and the Tittabawassee River floodplain in Michigan. The objective of this study is threefold: (1) to evaluate dioxin levels in soils; (2) to evaluate the spatial variations in breast cancer incidence in Midland, Saginaw, and Bay Counties in Michigan; (3) to evaluate whether breast cancer rates are spatially associated with the dioxin contamination areas.
methodsWe acquired 532 published soil dioxin data samples collected from 1995 to 2003 and data pertaining to female breast cancer cases (n = 4,604) at ZIP code level in Midland, Saginaw, and Bay Counties for years 1985 through 2002. Descriptive statistics and self-organizing map algorithm were used to evaluate dioxin levels in soils. Geographic information systems techniques, the Kulldorff's spatial and space-time scan statistics, and genetic algorithms were used to explore the variation in the incidence of breast cancer in space and space-time. Odds ratio and their corresponding 95% confidence intervals, with adjustment for age, were used to investigate a spatial association between breast cancer incidence and soil dioxin contamination.
resultsHigh levels of dioxin in soils were observed in the city of Midland and the Tittabawassee River 100-year floodplain. After adjusting for age, we observed high breast cancer incidence rates and detected the presence of spatial clusters in the city of Midland, the confluence area of the Tittabawassee, and Saginaw Rivers. After accounting for spatiotemporal variations, we observed a spatial cluster of breast cancer incidence in Midland between 1985 and 1993. The odds ratio further suggests a statistically significant (alpha = 0.05) increased breast cancer rate as women get older, and a higher disease burden in Midland and the surrounding areas in close proximity to the dioxin contaminated areas.
conclusionThese findings suggest that increased breast cancer incidences are spatially associated with soil dioxin contamination. Aging is a substantial factor in the development of breast cancer. Findings can be used for heightened surveillance and education, as well as formulating new study hypotheses for further research.
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