ArticleThe Plant journal : for cell and molecular biology2009
MS/MS spectral tag-based annotation of non-targeted profile of plant secondary metabolites.
Article in The Plant journal : for cell and molecular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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Who cites it
81 citing papers in PubMed.
- Analysis of Modified Plant Metabolites Using Widely Targeted Metabolite Modificomics.Bio-protocol · 2025Article
- Milletomics: a metabolomics centered integrated omics approach toward genetic progression.Functional & integrative genomics · 2024Review
- PlantMetSuite: A User-Friendly Web-Based Tool for Metabolomics Analysis and Visualisation.Plants (Basel, Switzerland) · 2023Article
- Defects in autophagy lead to selective in vivo changes in turnover of cytosolic and organelle proteins in Arabidopsis.The Plant cell · 2022Article
- Expanding the Coverage of Metabolic Landscape in Cultivated Rice with Integrated Computational Approaches.Genomics, proteomics & bioinformatics · 2022Article
- A metabolomic platform to identify and quantify polyphenols in coffee and related species using liquid chromatography mass spectrometry.Frontiers in plant science · 2022Article
- Erythrocyte Storage Lesion Improvements Mediated by Naringin Screened from Vegetable/Fruit Juice Using Cell Extract and HPLC-MS.Journal of analytical methods in chemistry · 2022Article
- Defective cytokinin signaling reprograms lipid and flavonoid gene-to-metabolite networks to mitigate high salinity inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Seed-coat protective neolignans are produced by the dirigent protein AtDP1 and the laccase AtLAC5 in Arabidopsis.The Plant cell · 2021Article
- Metabolite Profiling and Transcriptome Analyses Provide Insight Into Phenolic and Flavonoid Biosynthesis in the Nutshell of Macadamia Ternifolia.Frontiers in genetics · 2021Article
- Metabolomic Elucidation of the Effect of Sucrose on the Secondary Metabolite Profiles inACS omega · 2020Article
- Article
- Development of a plasma pseudotargeted metabolomics method based on ultra-high-performance liquid chromatography-mass spectrometry.Nature protocols · 2020Article
- Metabolomics in the Context of Plant Natural Products Research: From Sample Preparation to Metabolite Analysis.Metabolites · 2020Review
- Comparative analysis of metabolome of rice seeds at three developmental stages using a recombinant inbred line population.The Plant journal : for cell and molecular biology · 2019Article
- The MYB Activator WHITE PETAL1 Associates with MtTT8 and MtWD40-1 to Regulate Carotenoid-Derived Flower Pigmentation inThe Plant cell · 2019Article
- Placenta, Pericarp, and Seeds of Tabasco Chili Pepper Fruits Show a Contrasting Diversity of Bioactive Metabolites.Metabolites · 2019Article
- Glucosinolate Distribution in the Aerial Parts ofPlants (Basel, Switzerland) · 2019Article
- Identification and characterization of metabolite quantitative trait loci in tomato leaves and comparison with those reported for fruits and seeds.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Insights into Tissue-specific Specialized Metabolism in Tieguanyin Tea Cultivar by Untargeted Metabolomics.Molecules (Basel, Switzerland) · 2018Article
21 more citing papers are in PubMed but not listed here.
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6 authors.
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Abstract
The MS/MS spectral tag (MS2T) library-based peak annotation procedure was developed for informative non-targeted metabolic profiling analysis using LC-MS. An MS2T library of Arabidopsis metabolites was created from a set of MS/MS spectra acquired using the automatic data acquisition function of the mass spectrometer. By using this library, we obtained structural information for the detected peaks in the metabolic profile data without performing additional MS/MS analysis; this was achieved by searching for the corresponding MS2T accession in the library. In the case of metabolic profile data for Arabidopsis tissues containing more than 1000 peaks, approximately 50% of the peaks were tagged by MS2Ts, and 90 peaks were identified or tentatively annotated with metabolite information by searching the metabolite databases and manually interpreting the MS2Ts. A comparison of metabolic profiles among the Arabidopsis tissues revealed that many unknown metabolites accumulated in a tissue-specific manner, some of which were deduced to be unusual Arabidopsis metabolites based on the MS2T data. Candidate genes responsible for these biosyntheses could be predicted by projecting the results to the transcriptome data. The method was also used for metabolic phenotyping of a subset of Ds transposon-inserted lines of Arabidopsis, resulting in clarification of the functions of reported genes involved in glycosylation of flavonoids. Thus, non-targeted metabolic profiling analysis using MS2T annotation methods could prove to be useful for investigating novel functions of secondary metabolites in plants.
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