ArticleTraffic (Copenhagen, Denmark)2009
The dynamics and mechanisms of interleukin-1alpha and beta nuclear import.
Article in Traffic (Copenhagen, Denmark), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- An ancient evolutionary origin for IL-1 cytokines.Nature ecology & evolution · 2026Article
- C-terminal interleukin 1 alpha (IL-1α) overexpression drives EMT and a vulnerability to ferroptosis in HNSCC.Redox biology · 2026Article
- Inflammatory responses following CRISPR modification of the nuclear localisation sequence in endogenous interleukin-1 alpha.Disease models & mechanisms · 2026Article
- Endothelial Biomarkers and Cytokine Profiles: Signatures of Mortality in Severe COVID-19.International journal of molecular sciences · 2026Observational
- Activation of integrin signaling up-regulates pro-inflammatory cytokines in JAK2-V617F positive hematopoietic cells.Cell communication and signaling : CCS · 2025Article
- Proximity labelling of pro-interleukin-1α reveals evolutionary conserved nuclear interactions.Nature communications · 2024Article
- Analysis of the effects of importin α1 on the nuclear translocation of IL-1α in HeLa cells.Scientific reports · 2024Article
- Decoy Receptor 3 Promotes Preosteoclast Cell Death via Reactive Oxygen Species-Induced Fas Ligand Expression and the IL-1Mediators of inflammation · 2020Article
- Post-stroke inflammation-target or tool for therapy?Acta neuropathologica · 2019Review
- Critical role of IL-1α in IL-1β-induced inflammatory responses: cooperation with NF-κBp65 in transcriptional regulation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Impact of Nuclear Interleukin-1 Alpha and EGFR Expression on Recurrence and Survival Outcomes in Oral Squamous Cell Carcinomas.Journal of oncology · 2019Article
- Redefining the ancestral origins of the interleukin-1 superfamily.Nature communications · 2018Article
- Function and regulation of IL-1α in inflammatory diseases and cancer.Immunological reviews · 2018Review
- CRISPR/Cas9 mediated mutation of mouse IL-1α nuclear localisation sequence abolishes expression.Scientific reports · 2017Article
- Unconventional Pathways of Secretion Contribute to Inflammation.International journal of molecular sciences · 2017Review
- Interleukin 1α and the inflammatory process.Nature immunology · 2016Review
- Role of brain transmigrating neutrophils in depression-like behavior during systemic infection.Molecular psychiatry · 2014Article
- The biology of interleukin-1: emerging concepts in the regulation of the actin cytoskeleton and cell junction dynamics.Cellular and molecular life sciences : CMLS · 2012Review
- IL-1 receptor regulates S100A8/A9-dependent keratinocyte resistance to bacterial invasion.Mucosal immunology · 2012Article
- Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues.Journal of neuroinflammation · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Pro-inflammatory members of the interleukin-1 (IL-1) family of cytokines (IL-1alpha and beta) are important mediators of host defense responses to infection but can also exacerbate the damaging inflammation that contributes to major human diseases. IL-1alpha and beta are produced by cells of the innate immune system, such as macrophages, and act largely after their secretion by binding to the type I IL-1 receptor on responsive cells. There is evidence that IL-1alpha is also a nuclear protein that can act intracellularly. In this study, we report that both IL-1alpha and IL-1beta produced by microglia (central nervous system macrophages) in response to an inflammatory challenge are distributed between the cytosol and the nucleus. Using IL-1-beta-galactosidase and IL-1-green fluorescent protein chimeras (analyzed by fluorescence recovery after photobleaching), we demonstrate that nuclear import of IL-1alpha is exclusively active, requiring a nuclear localization sequence and Ran, while IL-1beta nuclear import is entirely passive. These data provide valuable insights into the dynamic regulation of intracellular cytokine trafficking.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.