ArticleChromosoma1991
Two-color hybridization with high complexity chromosome-specific probes and a degenerate alpha satellite probe DNA allows unambiguous discrimination between symmetrical and asymmetrical translocations.
Article in Chromosoma, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 81 citations in OpenAlex.
- Clinical application of a lung cancer organoid (tumoroid) culture system.NPJ precision oncology · 2021Article
- Nucleolar organization, ribosomal DNA array stability, and acrocentric chromosome integrity are linked to telomere function.PloS one · 2014Article
- Clinical and mutation analysis of 51 probands with anophthalmia and/or severe microphthalmia from a single center.Molecular genetics & genomic medicine · 2013Article
- Bioinformatics tools allow targeted selection of chromosome enumeration probes and aneuploidy detection.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2013Article
- Chromosome-specific DNA repeats: rapid identification in silico and validation using fluorescence in situ hybridization.International journal of molecular sciences · 2012Article
- Bioinformatic Tools Identify Chromosome-Specific DNA Probes and Facilitate Risk Assessment by Detecting Aneusomies in Extra-embryonic Tissues.Current genomics · 2012Article
- Scaffold-free human cardiac tissue patch created from embryonic stem cells.Tissue engineering. Part A · 2009Article
- Systems approaches to preventing transplanted cell death in cardiac repair.Journal of molecular and cellular cardiology · 2008Review
- Thr11 phosphorylated H3 is associated with centromere DNA during mitosis in MCF-7 cells.Molecular and cellular biochemistry · 2008Article
- Human artificial chromosomes with alpha satellite-based de novo centromeres show increased frequency of nondisjunction and anaphase lag.Molecular and cellular biology · 2003Article
- The development of chromosome-specific composite DNA probes for the mouse and their application to chromosome painting.Chromosoma · 1993Article
- Engraftment and long-term expression of human fetal hemopoietic stem cells in sheep following transplantation in utero.The Journal of clinical investigation · 1992Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
This report describes a fluorescence in situ hybridization approach to chromosome staining that facilitates detection of structural aberrations and allows discrimination between dicentric chromosomes and symmetrically translocated chromosomes. In this approach, selected whole chromosomes are stained in one color by hybridization with composite probes whose elements have DNA sequence homology along the length of the target chromosomes. In addition, all chromosomes are counterstained with a DNA specific dye so that structural aberrations between target and non-target chromosomes are clearly visible. Discrimination between dicentric chromosomes and symmetrical translocations is accomplished by hybridization with a second probe that is homologous to DNA sequences found in the centromeric region of all chromosomes. The centromeric marker is visualized in a different color, so that the number of centromeres per aberrant chromosome can be rapidly determined in the microscope by changing excitation and fluorescence filters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.