ArticleChromosoma1991
CENP-B is a highly conserved mammalian centromere protein with homology to the helix-loop-helix family of proteins.
Article in Chromosoma, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 119 citations in OpenAlex.
- Rapid centromere turnover and the adaptive radiation of lemurs.bioRxiv : the preprint server for biology · 2026Article
- The complete genome of a songbird.bioRxiv : the preprint server for biology · 2025Article
- Centromeres in cancer: Unraveling the link between chromosomal instability and tumorigenesis.Medical oncology (Northwood, London, England) · 2024Review
- Transposon-derived transcription factors across metazoans.Frontiers in cell and developmental biology · 2023Article
- Anticentromere antibody induced by immunization with centromere protein and Freund's complete adjuvant may interfere with mouse early-stage embryo.Reproductive biology and endocrinology : RB&E · 2021Article
- Genomic Tackling of Human Satellite DNA: Breaking Barriers through Time.International journal of molecular sciences · 2021Review
- Centromeres under Pressure: Evolutionary Innovation in Conflict with Conserved Function.Genes · 2020Review
- Processive DNA synthesis is associated with localized decompaction of constitutive heterochromatin at the sites of DNA replication and repair.Nucleus (Austin, Tex.) · 2019Article
- Non-B-Form DNA Is Enriched at Centromeres.Molecular biology and evolution · 2018Article
- Epigenetic Regulation of Centromere Chromatin Stability by Dietary and Environmental Factors.Advances in nutrition (Bethesda, Md.) · 2017Review
- CENP-B box, a nucleotide motif involved in centromere formation, occurs in a New World monkey.Biology letters · 2016Article
- Alteration/Deficiency in Activation 3 (ADA3) Protein, a Cell Cycle Regulator, Associates with the Centromere through CENP-B and Regulates Chromosome Segregation.The Journal of biological chemistry · 2015Article
- DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function.Developmental cell · 2015Article
- Identification of novel α-n-methylation of CENP-B that regulates its binding to the centromeric DNA.Journal of proteome research · 2013Article
- HACking the centromere chromatin code: insights from human artificial chromosomes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Review
- Convergent domestication of pogo-like transposases into centromere-binding proteins in fission yeast and mammals.Molecular biology and evolution · 2008Article
- Anti-CENP-H antibodies in patients with Sjogren's syndrome.Rheumatology international · 2006Article
- Cell cycle and centromere FISH studies in premature centromere division.BMC medical genetics · 2005Article
- Jerky, a protein deficient in a mouse epilepsy model, is associated with translationally inactive mRNA in neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Uterine dysfunction and genetic modifiers in centromere protein B-deficient mice.Genome research · 2000Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
CENP-B is a centromere associated protein originally identified in human cells as an 80 kDa autoantigen recognized by sera from patients with anti-centromere antibodies (ACA). Recent evidence indicates that CENP-B interacts with centromeric heterochromatin in human chromosomes and may bind to a specific subset of human alphoid satellite DNA. CENP-B has not been unambiguously identified in non-primates and could, in principal, be a primate-specific alphoid DNA binding protein. In this work, a human genomic DNA segment containing the CENP-B gene was isolated and subjected to DNA sequence analysis. In vitro expression identified the site for translation initiation of CENP-B, demonstrating that it is encoded by an intronless open reading frame (ORF) in human DNA. A homologous mouse gene was also isolated and characterized. It was found to possess a high degree of homology with the human gene, containing an intronless ORF coding for a 599 residue polypeptide with 96% sequence similarity to human CENP-B. 5' and 3' flanking and untranslated sequences were conserved at a level of 94.6% and 82.7%, respectively, suggesting that the regulatory properties of CENP-B may be conserved as well. CENP-B mRNA was detected in mouse cells and tissues and an immunoreactive nuclear protein identical in size to human CENP-B was detected in mouse 3T3 cells using human ACA. Analysis of the sequence of CENP-B revealed a segment of significant similarity to a DNA binding motif identified for the helix-loop-helix (HLH) family of DNA binding proteins. These data demonstrate that CENP-B is a highly conserved mammalian protein that may be a member of the HLH protein family and suggest that it plays a role in a conserved aspect of centromere structure or function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.