ReviewCurrent atherosclerosis reports2008
Intakes of long-chain omega-3 fatty acid associated with reduced risk for death from coronary heart disease in healthy adults.
Review in Current atherosclerosis reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 196 citations in OpenAlex.
- Marine Oil fromNutrients · 2022Trial
- Hemodialysis and erythrocyte epoxy fatty acids.Physiological reports · 2020Trial
- Omega-3 fatty acid exposure with a low-fat diet in patients with past hypertriglyceridemia-induced acute pancreatitis; an exploratory, randomized, open-label crossover study.Lipids in health and disease · 2020Trial
- Effect of Fish Oil Supplementation on Hepatic and Visceral Fat in Overweight Men: A Randomized Controlled Trial.Nutrients · 2019Trial
- A novel self-micro-emulsifying delivery system (SMEDS) formulation significantly improves the fasting absorption of EPA and DHA from a single dose of an omega-3 ethyl ester concentrate.Lipids in health and disease · 2017Trial
- A telephone-supported cardiovascular lifestyle programme (CLIP) for lipid reduction and weight loss in general practice patients: a randomised controlled pilot trial.Public health nutrition · 2014Trial
- Trial
- Docosahexaenoic acid supplementation, vascular function and risk factors for cardiovascular disease: a randomized controlled trial in young adults.Journal of the American Heart Association · 2013Trial
- Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially.Journal of the Academy of Nutrition and Dietetics · 2013Trial
- Alpha-linolenic acid: is it essential to cardiovascular health?Current atherosclerosis reports · 2010Trial
- Low-Dose Dietary Fish Oil Improves RBC Deformability without Improving Post-Transfusion Recovery in Mice.Nutrients · 2023Article
- Article
- Study on bioactive compounds of microalgae as antioxidants in a bibliometric analysis and visualization perspective.Frontiers in plant science · 2023Review
- Associations of plasma omega-3 and omega-6 pufa levels with arterial elasticity: the multi-ethnic study of atherosclerosis.European journal of clinical nutrition · 2022Article
- Bioaccumulation of Blood Long-Chain Fatty Acids during Hemodialysis.Metabolites · 2022Article
- Article
- Effects of hemodialysis on blood fatty acids.Physiological reports · 2020Article
- The benefits of marine omega-3s for preventing arrhythmias.Open heart · 2020Article
- Biochemical impacts in adult and juvenile farmed European seabass and gilthead seabream from semi-intensive aquaculture of southern European estuarine systems.Environmental science and pollution research international · 2019Article
- Impact of Blood or Erythrocyte Membrane Fatty Acids for Disease Risk Prediction: Focusing on Cardiovascular Disease and Chronic Kidney Disease.Nutrients · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous organizations and national health agencies have begun to recommend consumption of the long-chain omega-3 fatty acids (FAs) eicosapentaenoic acid and docosahexaenoic acid (EPA and DHA), respectively, in pill or fish form for general cardiovascular health. The purpose of this article is to present a rationale for an official target intake of 400 to 500 mg/d of EPA + DHA in the United States. Six epidemiologic studies reporting EPA + DHA intake and risk of coronary heart disease (CHD) death have been conducted in the United States, and five studies reported statistically significant inverse trends. Meta-analysis of these data showed a significant dose-response relationship between risk for CHD death and intake (P = 0.03), with relative risk reductions of 37% at an average EPA + DHA intake of 566 mg/d. Coincidentally, two servings per week of oily fish (the current American Heart Association recommendation) would provide 400 to 500 mg/d. We conclude, therefore, that an intake of 400 to 500 mg/d of EPA + DHA is achievable by diet alone and would be expected to significantly reduce risk for death from CHD in healthy adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.