ArticleJournal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research2008
Rigid interferon-alpha subtype responses of human plasmacytoid dendritic cells.
Article in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Immunostimulation of Asian elephant (Frontiers in immunology · 2024Article
- Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption.Science translational medicine · 2021Article
- Shared and Unique Features of Human Interferon-Beta and Interferon-Alpha Subtypes.Frontiers in immunology · 2020Review
- Article
- Regulation of Early Host Immune Responses Shapes the Pathogenicity of Avian Influenza A Virus.Frontiers in microbiology · 2019Article
- Immune evasion of porcine enteric coronaviruses and viral modulation of antiviral innate signaling.Virus research · 2016Review
- Early treatment with reverse transcriptase inhibitors significantly suppresses peak plasma IFNα in vivo during acute simian immunodeficiency virus infection.Cellular immunology · 2016Article
- Virus Multiplicity of Infection Affects Type I Interferon Subtype Induction Profiles and Interferon-Stimulated Genes.Journal of virology · 2015Article
- Review
- Interferons and viruses: an evolutionary arms race of molecular interactions.Trends in immunology · 2015Review
- Interferon-α Subtypes in an Ex Vivo Model of Acute HIV-1 Infection: Expression, Potency and Effector Mechanisms.PLoS pathogens · 2015Article
- Induction of IFN-α subtypes and their antiviral activity in mumps virus infection.Viral immunology · 2014Article
- Plasmacytoid dendritic cells of the gut: relevance to immunity and pathology.Clinical immunology (Orlando, Fla.) · 2014Review
- Impact of genotype 1 and 2 of porcine reproductive and respiratory syndrome viruses on interferon-α responses by plasmacytoid dendritic cells.Veterinary research · 2013Article
- IFN-α subtypes: distinct biological activities in anti-viral therapy.British journal of pharmacology · 2013Review
- Tissue-specific interferon alpha subtype response to SIV infection in brain, spleen, and lung.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2013Article
- Expression profiles of human interferon-alpha and interferon-lambda subtypes are ligand- and cell-dependent.Immunology and cell biology · 2012Article
- Simian immunodeficiency virus infection in the brain and lung leads to differential type I IFN signaling during acute infection.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- The differential activity of interferon-α subtypes is consistent among distinct target genes and cell types.Cytokine · 2011Article
- The early interferon alpha subtype response in infant macaques infected orally with SIV.Journal of acquired immune deficiency syndromes (1999) · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The large family of human type I interferon (IFN) includes 13 distinct subtypes of IFN-alpha, all utilizing a single type I IFN receptor. Many viruses have created evasion strategies to disable this cytokine family, highlighting their importance in antiviral defense. It is unclear what advantage the presence of so many different IFN-alpha subtypes provides, but functional differences observed among individual IFN-alpha subtypes suggested that they might play distinct regulatory roles during an immune response. To determine whether IFN-alpha subtype responses differ depending on a particular type of insult and thus whether IFN-alpha subtype responses are flexible to adapt to distinct pathogen challenges, we developed a novel nested multiplex reverse transcriptase polymerase chain reaction assay with which we measured expression of all IFN-alpha subtypes by freshly isolated human plasmacytoid dendritic cells (pDCs), a main source of IFN-alpha following pathogen challenge. Collectively our data show a remarkable stability in the relative magnitude and the kinetics of induction for each IFN-alpha subtype produced by pDC. Although various stimuli used, A-, B- and C-class CpGs, live and heat-inactivated influenza viruses and the TLR7 agonist R837 affected the overall magnitude of the response, each IFN-alpha subtype was induced at statistically similar relative levels and with similar kinetics, thereby revealing a great degree of rigidity in the IFN-alpha response pattern of pDC. These data are most consistent with the induction of optimized ratios of IFN-alpha subtypes, each of which may have differing signaling properties or alternatively, a great degree of redundancy in the IFN-alpha response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.