ArticleBirth defects research. Part A, Clinical and molecular teratology2008
Wnt signaling in caudal dysgenesis and diabetic embryopathy.
Article in Birth defects research. Part A, Clinical and molecular teratology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- High glucose impairs osteogenic differentiation of embryonic stem cells via early diversion of beta-catenin from Forkhead box O to T cell factor interaction.Birth defects research · 2022Article
- Downregulation of hsa_circ_0005243 induces trophoblast cell dysfunction and inflammation via the β-catenin and NF-κB pathways.Reproductive biology and endocrinology : RB&E · 2020Article
- Embryonic cell migratory capacity is impaired upon exposure to glucose in vivo and in vitro.Birth defects research · 2019Article
- CTRP9 Regulates Growth, Differentiation, and Apoptosis in Human Keratinocytes through TGFβ1-p38-Dependent Pathway.Molecules and cells · 2017Article
- Maternal diabetes causes developmental delay and death in early-somite mouse embryos.Scientific reports · 2017Article
- The status of diabetic embryopathy.Upsala journal of medical sciences · 2016Review
- Superoxide Dismutase 1 In Vivo Ameliorates Maternal Diabetes Mellitus-Induced Apoptosis and Heart Defects Through Restoration of Impaired Wnt Signaling.Circulation. Cardiovascular genetics · 2015Article
- The effect of maternal diabetes on the Wnt-PCP pathway during embryogenesis as reflected in the developing mouse eye.Disease models & mechanisms · 2015Article
- TGFβ and Wnt in cardiac outflow tract defects in offspring of diabetic pregnancies.Birth defects research. Part B, Developmental and reproductive toxicology · 2014Article
- Modeling anterior development in mice: diet as modulator of risk for neural tube defects.American journal of medical genetics. Part C, Seminars in medical genetics · 2013Review
- Trehalose prevents neural tube defects by correcting maternal diabetes-suppressed autophagy and neurogenesis.American journal of physiology. Endocrinology and metabolism · 2013Article
- Responses of the embryonic epigenome to maternal diabetes.Birth defects research. Part A, Clinical and molecular teratology · 2012Article
- Oxidative stress-induced JNK1/2 activation triggers proapoptotic signaling and apoptosis that leads to diabetic embryopathy.Diabetes · 2012Article
- Strain-specific modifier genes governing craniofacial phenotypes.Birth defects research. Part A, Clinical and molecular teratology · 2012Article
- Diabetic embryopathy: a role for the epigenome?Birth defects research. Part A, Clinical and molecular teratology · 2011Review
- Maternal diet modulates the risk for neural tube defects in a mouse model of diabetic pregnancy.Reproductive toxicology (Elmsford, N.Y.) · 2011Article
- Neural tube defect genes and maternal diabetes during pregnancy.Birth defects research. Part A, Clinical and molecular teratology · 2010Article
- Maternal diabetes alters transcriptional programs in the developing embryo.BMC genomics · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCongenital defects are a major complication of diabetic pregnancy, and the leading cause of infant death in the first year of life. Caudal dysgenesis, occurring up to 200-fold more frequently in children born to diabetic mothers, is a hallmark of diabetic pregnancy. Given that there is also an at least threefold higher risk for heart defects and NTDs, it is important to identify the underlying molecular mechanisms for aberrant embryonic development.
methodsWe have investigated gene expression in a transgenic mouse model of caudal dysgenesis, and in a pharmacological model using situ hybridization and quantitative real-time PCR.
resultsWe identified altered expression of several molecules that control developmental processes and embryonic growth.
conclusionsThe results from our models point towards major implication of altered Wnt signaling in the pathogenesis of developmental anomalies associated with embryonic exposure to maternal diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.