ArticleCell motility and the cytoskeleton2008
Disparate effects of different mutations in plakoglobin on cell mechanical behavior.
Article in Cell motility and the cytoskeleton, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Inhibition of Soluble Epoxide Hydrolase Reduces Inflammation and Myocardial Injury in Arrhythmogenic Cardiomyopathy.JACC. Basic to translational science · 2025Article
- Naxos Disease and Related Cardio-Cutaneous Syndromes.JACC. Advances · 2025Review
- Article
- Defective Desmosomal Adhesion Causes Arrhythmogenic Cardiomyopathy by Involving an Integrin-αVβ6/TGF-β Signaling Cascade.Circulation · 2022Article
- Towards a Better Understanding of Genotype-Phenotype Correlations and Therapeutic Targets for Cardiocutaneous Genes: The Importance of Functional Studies above Prediction.International journal of molecular sciences · 2022Review
- Arrhythmogenic Cardiomyopathy: Molecular Insights for Improved Therapeutic Design.Journal of cardiovascular development and disease · 2020Review
- Molecular mechanisms of arrhythmogenic cardiomyopathy.Nature reviews. Cardiology · 2019Review
- Arrhythmogenic right ventricular cardiomyopathy mutations alter shear response without changes in cell-cell adhesion.Cardiovascular research · 2014Article
- Characterization of partially lifted cell sheets.Tissue engineering. Part A · 2014Article
- Remodeling of cell-cell junctions in arrhythmogenic cardiomyopathy.Cell communication & adhesion · 2014Review
- Keratinocyte cytoskeletal roles in cell sheet engineering.BMC biotechnology · 2013Article
- Beyond cell adhesion: the role of armadillo proteins in the heart.Cellular signalling · 2013Review
- Analysis of a Jup hypomorphic allele reveals a critical threshold for postnatal viability.Genesis (New York, N.Y. : 2000) · 2012Article
- High motility of triple-negative breast cancer cells is due to repression of plakoglobin gene by metastasis modulator protein SLUG.The Journal of biological chemistry · 2012Article
- Depth-resolved cellular microrheology using HiLo microscopy.Biomedical optics express · 2012Article
- Mutations with pathogenic potential in proteins located in or at the composite junctions of the intercalated disk connecting mammalian cardiomyocytes: a reference thesaurus for arrhythmogenic cardiomyopathies and for Naxos and Carvajal diseases.Cell and tissue research · 2012Review
- Article
- Plakophilin-2 and the migration, differentiation and transformation of cells derived from the epicardium of neonatal rat hearts.Cell communication & adhesion · 2011Article
- Cell-cell contact preserves cell viability via plakoglobin.PloS one · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Mutations in genes encoding desmosomal proteins have been implicated in the pathogenesis of heart and skin diseases. This has led to the hypothesis that defective cell-cell adhesion is the underlying cause of injury in tissues that repeatedly bear high mechanical loads. In this study, we examined the effects of two different mutations in plakoglobin on cell migration, stiffness, and adhesion. One is a C-terminal mutation causing Naxos disease, a recessive syndrome of arrhythmogenic right ventricular cardiomyopathy (ARVC) and abnormal skin and hair. The other is an N-terminal mutation causing dominant inheritance of ARVC without cutaneous abnormalities. To assess the effects of plakoglobin mutations on a broad range of cell mechanical behavior, we characterized a model system consisting of stably transfected HEK cells which are particularly well suited for analyses of cell migration and adhesion. Both mutations increased the speed of wound healing which appeared to be related to increased cell motility rather than increased cell proliferation. However, the C-terminal mutation led to dramatically decreased cell-cell adhesion, whereas the N-terminal mutation caused a decrease in cell stiffness. These results indicate that different mutations in plakoglobin have markedly disparate effects on cell mechanical behavior, suggesting complex biomechanical roles for this protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.