ArticleChromosoma2009
Reorganization of chromatin is an early response to nitrogen starvation in Schizosaccharomyces pombe.
Article in Chromosoma, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Nuclear Dynamics in Quiescent Cells: Conserved Mechanisms from Yeasts to Mammals.Biomolecules · 2026Review
- The contribution of non-essentialOpen biology · 2018Article
- Tracking the evolution of 3D gene organization demonstrates its connection to phenotypic divergence.Nucleic acids research · 2017Article
- Histones and histone modifications in perinuclear chromatin anchoring: from yeast to man.EMBO reports · 2016Review
- Control of heterochromatin localization and silencing by the nuclear membrane protein Lem2.Genes & development · 2016Article
- Chromosome domain architecture and dynamic organization of the fission yeast genome.FEBS letters · 2015Review
- Epigenetic Regulation of Chromatin States in Schizosaccharomyces pombe.Cold Spring Harbor perspectives in biology · 2015Review
- Chromosome conformation maps in fission yeast reveal cell cycle dependent sub nuclear structure.Nucleic acids research · 2014Article
- Article
- The links between chromatin spatial organization and biological function.Biochemical Society transactions · 2013Review
- Subnuclear relocalization and silencing of a chromosomal region by an ectopic ribosomal DNA repeat.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- HDAC-mediated suppression of histone turnover promotes epigenetic stability of heterochromatin.Nature structural & molecular biology · 2013Article
- Quantitative live cell fluorescence-microscopy analysis of fission yeast.Journal of visualized experiments : JoVE · 2012Article
- Advancing our understanding of functional genome organisation through studies in the fission yeast.Current genetics · 2011Review
- A second protein disulfide isomerase plays a protective role against nitrosative and nutritional stresses in Schizosaccharomyces pombe.Molecular biology reports · 2010Article
- Nitrogen depletion in the fission yeast Schizosaccharomyces pombe causes nucleosome loss in both promoters and coding regions of activated genes.Genome research · 2010Article
- Transcriptional regulation at the yeast nuclear envelope.Nucleus (Austin, Tex.)Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are several documented events of changes in subnuclear localization during gene activation. However, there are conflicting data on whether the nuclear periphery is a compartment for gene repression or activation and whether genes are moved to the pores at the nuclear membrane (NM) or not during gene activation. Nitrogen starvation of fission yeast serves as a good model system for studying gene induction, as it causes fast regulation of hundreds of genes. In this study, the subnuclear localization of two gene clusters repressed by nitrogen was investigated. During normal growth conditions, the gene clusters localized to the nuclear periphery at the opposite side of the nucleus as compared to the spindle pole body. This constrained localization was dependent on the histone deacetylase Clr3, known to transcriptionally repress genes in these clusters. Already 20 min after nitrogen depletion, drastic changes in subnuclear localization of the two loci were observed, away from the NM toward the nuclear interior. At least for one of the clusters, the movement was clearly transcription dependent. Data presented in this paper illustrates how interconnected events of gene activation and nuclear reorganization are as well as provides a suggestion of how nuclear organization might be maintained.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.