ArticleInternational journal of obesity (2005)2008
Latent common genetic components of obesity traits.
Article in International journal of obesity (2005), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Assessing genetic and environmental influences on epicardial and abdominal adipose tissue quantities: a classical twin study.International journal of obesity (2005) · 2018Article
- Using a Bayesian latent variable approach to detect pleiotropy in the Genetic Analysis Workshop 18 data.BMC proceedings · 2014Article
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5 authors.
Funding
Abstract
backgroundObesity is rapidly becoming a global epidemic. Unlike many complex human diseases, obesity is defined not just by a single trait or phenotype, but jointly by measures of anthropometry and metabolic status.
methodsWe applied maximum likelihood factor analysis to identify common latent factors underlying observed covariance in multiple obesity-related measures. Both the genetic components and the mode of inheritance of the common factors were evaluated. A total of 1775 participants from 590 families for whom measures on obesity-related traits were available were included in this study.
resultsThe average age of participants was 37 years, 39% of the participants were obese (body mass index >or= 30.0 kg/m(2)) and 26% were overweight (body mass index 25.0-29.9 kg/m(2)). Two latent common factors jointly accounting for over 99% of the correlations among obesity-related traits were identified. Complex segregation analysis of the age- and sex-adjusted latent factors provide evidence for a Mendelian mode of inheritance of major genetic effect with heritability estimates of 40.4 and 47.5% for the first and second factors, respectively.
conclusionsThese findings provide a support for multivariate-based approach for investigating pleiotropic effects on obesity-related traits, which can be applied in both genetic linkage and association mapping.
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