Evidence map›Paper›PMID 18936734›Full record

ArticleBone marrow transplantation2009

Predictors of mortality in patients undergoing autologous hematopoietic cell transplantation admitted to the intensive care unit.

M A Trinkaus, S E Lapinsky, M Crump, A Keating, D E Reece, C Chen, D C Hallett, N Franke, A Winter, J R Mikhael

Registry-linked trialAbstract read
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In one paragraph

Article in Bone marrow transplantation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03449953 (Critical Care Outcomes of Patients With Hematologic Malignancy and Hematopoietic Cell Transplantation), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03449953 active not recruitingnot on this mapstarted 2018, after this paper: background citation

Critical Care Outcomes of Patients With Hematologic Malignancy and Hematopoietic Cell Transplantation

TypeobservationalSponsorMount Sinai Hospital, CanadaRan2018 to 2026Enrolled415ConditionsHematologic Malignancy, Stem Cell Transplant
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 51 citations in OpenAlex.

  1. Characterization and outcomes of severe complications after autologous hematopoietic stem-cell transplantation: a retrospective multicenter study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Observational
  2. Intensive care unit admission rates and factors associated following Autologous stem cell transplantation-real-world experience from a tertiary center in rural India.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  3. Prognostic Factors and Intensive Care Outcome in Post-Transplant Phase of Hematopoietic Stem Cell Transplantation: Intensive Care Outcome in Hematopoietic Stem Cell Transplantation.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

M A TrinkausUniversity of Toronto Autologous Blood and Marrow Transplant Program, Princess Margaret Hospital, Toronto, Canada. martina.trinkaus@utoronto.ca
S E Lapinsky
M Crump
A Keating
D E Reece
C Chen
D C Hallett
N Franke
A Winter
J R Mikhael
University of Toronto · CAMount Sinai Hospital · CAPrincess Margaret Cancer Centre · CAMayo Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Between January 2001 and July 2006, 1013 patients received autologous hematopoietic cell transplants (AHCT) at Canada's largest transplant center. In this retrospective cohort study of AHCT patients admitted to the intensive care unit (ICU), we describe the outcomes following ICU admission and the variables measured in the first 24 h of ICU admission associated with overall ICU mortality. Results indicate a 3.3% ICU admission rate (n=34) with 13 deaths (1% overall mortality rate, 38% in ICU mortality rate). The worst outcome was in AL amyloid patients of whom 28% were admitted to the ICU, with an ICU mortality rate of 55%. The Sequential Organ Failure Assessment (SOFA) score and Acute Physiology and Chronic Health Evaluation (APACHE II) score in the first 24 h were statistically associated with mortality by univariate analysis. Other variables measured at 24 h and associated with ICU mortality included multiorgan failure, mechanical ventilation, inotropic support >4 h and Gram-negative sepsis. Our data indicate that ICU admission in the autotransplant population is rare and that it is influenced by underlying diagnosis, with AL amyloid patients having the highest risk. Our observations may assist clinical decision-making regarding the continuation of intensive care delivered 24 h after ICU admission.

Indexed as

AdultAgedFemaleHematopoietic Stem Cell TransplantationHospital MortalityHumansIntensive Care UnitsMaleMiddle AgedMultiple Organ FailureRespiration, ArtificialRetrospective StudiesTransplantation, Autologous

Identifiers

PMID18936734
OpenAlexW2080472475

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.