ArticleProceedings of the National Academy of Sciences of the United States of America2008
Repeated horizontal transfer of a DNA transposon in mammals and other tetrapods.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.
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120 citing papers in PubMed, 213 citations in OpenAlex.
- Horizontal gene transfer is widespread in diverse eukaryotes.BMC genomics · 2026Article
- Deciphering the dynamics of active autonomous terminal inverted repeat transposons in the plant kingdom.aBIOTECH · 2026Article
- Multiple Buster transposons from hAT superfamily displaying transposition activities in mammal cells.Synthetic and systems biotechnology · 2026Article
- Multi-species analysis of inflammatory response elements reveals ancient and lineage-specific contributions of transposable elements to NF-kB binding.Genome research · 2025Article
- Impact of a horizontally transferred Helitron family on genome evolution in Xenopus laevis.Mobile DNA · 2025Article
- Possible Horizontal Gene Transfer of Novel Transposable Elements inmicroPublication biology · 2025Article
- Deep mining reveals the diversity of endogenous viral elements in vertebrate genomes.Nature microbiology · 2024Article
- Characterization of hAT DNA transposon superfamily in the genome of Neotropical fish Apareiodon sp.Molecular genetics and genomics : MGG · 2024Article
- Article
- Horizontal transfer and the widespread presence of Galileo transposons in Drosophilidae (Insecta: Diptera).Genetics and molecular biology · 2024Article
- Jack of all trades versus master of one: how generalist versus specialist strategies of transposable elements relate to their horizontal transfer between lineages.Current opinion in genetics & development · 2023Review
- Chiropterans Are a Hotspot for Horizontal Transfer of DNA Transposons in Mammalia.Molecular biology and evolution · 2023Article
- P-element invasion fuels molecular adaptation in laboratory populations of Drosophila melanogaster.Evolution; international journal of organic evolution · 2023Article
- Genome Evolution and the Future of Phylogenomics of Non-Avian Reptiles.Animals : an open access journal from MDPI · 2023Review
- Genetic variation in P-element dysgenic sterility is associated with double-strand break repair and alternative splicing of TE transcripts.PLoS genetics · 2022Article
- Article
- Genome assembly of the Pendlebury's roundleaf bat, Hipposideros pendleburyi, revealed the expansion of Tc1/Mariner DNA transposons in Rhinolophoidea.DNA research : an international journal for rapid publication of reports on genes and genomes · 2022Article
- Evolution in small steps and giant leaps.Evolution; international journal of organic evolution · 2022Review
- Horizontal transfer and subsequent explosive expansion of a DNA transposon in sea kraits (Biology letters · 2021Article
- Generation of somatic mitochondrial DNA-replaced cells for mitochondrial dysfunction treatment.Scientific reports · 2021Article
60 more citing papers are in PubMed but not listed here.
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4 authors at 1 institution in 1 country.
Funding
Abstract
Horizontal transfer (HT) is central to the evolution of prokaryotic species. Selfish and mobile genetic elements, such as phages, plasmids, and transposons, are the primary vehicles for HT among prokaryotes. In multicellular eukaryotes, the prevalence and evolutionary significance of HT remain unclear. Here, we identified a set of DNA transposon families dubbed SPACE INVADERS (or SPIN) whose consensus sequences are approximately 96% identical over their entire length (2.9 kb) in the genomes of murine rodents (rat/mouse), bushbaby (prosimian primate), little brown bat (laurasiatherian), tenrec (afrotherian), opossum (marsupial), and two non-mammalian tetrapods (anole lizard and African clawed frog). In contrast, SPIN elements were undetectable in other species represented in the sequence databases, including 19 other mammals with draft whole-genome assemblies. This patchy distribution, coupled with the extreme level of SPIN identity in widely divergent tetrapods and the overall lack of selective constraint acting on these elements, is incompatible with vertical inheritance, but strongly indicative of multiple horizontal introductions. We show that these germline infiltrations likely occurred around the same evolutionary time (15-46 mya) and spawned some of the largest bursts of DNA transposon activity ever recorded in any species lineage (nearly 100,000 SPIN copies per haploid genome in tenrec). The process also led to the emergence of a new gene in the murine lineage derived from a SPIN transposase. In summary, HT of DNA transposons has contributed significantly to shaping and diversifying the genomes of multiple mammalian and tetrapod species.
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