ArticleCirculation2008
Molecular imaging of activated matrix metalloproteinases in vascular remodeling.
Article in Circulation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07473102 (PET Imaging of MMP Activation in AAA), which is not on this map. Cited by 56 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PET Imaging of MMP Activation in AAA: Clinical Component
Who cites it
56 citing papers in PubMed, 104 citations in OpenAlex.
- Molecular Imaging of Collagen Turnover in Myocardial Infarction.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- Molecular Imaging of Collagen Turnover in Myocardial Infarction.bioRxiv : the preprint server for biology · 2026Article
- In Vivo Cardiovascular Molecular Imaging: Contributions to Precision Medicine and Drug Development.Circulation · 2024Review
- Positron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm.Circulation. Cardiovascular imaging · 2023Article
- Using Molecular Targets to Predict and Treat Aortic Aneurysms.Reviews in cardiovascular medicine · 2022Review
- Selective Imaging of Matrix Metalloproteinase-13 to Detect Extracellular Matrix Remodeling in Atherosclerotic Lesions.Molecular imaging and biology · 2022Article
- Multi-Scale Imaging of Vascular Pathologies in Cardiovascular Disease.Frontiers in medicine · 2021Review
- Nicotine in Senescence and Atherosclerosis.Cells · 2020Review
- Article
- Association between epicardial adipose tissue and adverse outcomes in coronary heart disease patients with percutaneous coronary intervention.Bioscience reports · 2019Article
- Perspectives on Small Animal Radionuclide Imaging; Considerations and Advances in Atherosclerosis.Frontiers in medicine · 2019Review
- Current and Emerging Preclinical Approaches for Imaging-Based Characterization of Atherosclerosis.Molecular imaging and biology · 2018Review
- Molecular Imaging in Drug Discovery and Development.Circulation. Cardiovascular imaging · 2018Review
- Molecular targets in aortic aneurysm for establishing novel management paradigms.Journal of thoracic disease · 2017Review
- Optical imaging of MMP-12 active form in inflammation and aneurysm.Scientific reports · 2016Article
- High shear stress induces atherosclerotic vulnerable plaque formation through angiogenesis.Regenerative biomaterials · 2016Review
- Synthesis and in Vitro and in Vivo Evaluation of MMP-12 Selective Optical Probes.Bioconjugate chemistry · 2016Article
- Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology.Journal of clinical medicine · 2016Review
- Novel Molecular Imaging Approaches to Abdominal Aortic Aneurysm Risk Stratification.Circulation. Cardiovascular imaging · 2016Review
- Multimodality and molecular imaging of matrix metalloproteinase activation in calcific aortic valve disease.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMatrix metalloproteinase (MMP) activation plays a key role in vascular remodeling. RP782 is a novel indium (111)In-labeled tracer with specificity for activated MMPs. We hypothesized that RP782 can detect injury-induced vascular remodeling in vivo. METHODS AND
resultsLeft common carotid artery injury was induced with a guidewire in apolipoprotein E(-/-) mice. Sham surgery was performed on the contralateral artery, which served as control for imaging experiments. Carotid wire injury led to significant hyperplasia and expansive remodeling over a period of 4 weeks. MMP activity, detected by in situ zymography, increased in response to injury and was maximal by 3 to 4 weeks after injury. RP782 (11.1 MBq) was injected intravenously into apolipoprotein E(-/-) mice at 1, 2, 3, and 4 weeks after left carotid injury. MicroSPECT imaging was performed at 2 hours and was followed by CT angiography to localize the carotid arteries. In vivo images revealed focal uptake of RP782 in the injured carotid artery at 2, 3, and 4 weeks. Increased tracer uptake in the injured artery was confirmed by quantitative autoradiography. Pretreatment with 50-fold excess nonlabeled tracer significantly reduced RP782 uptake in injured carotids, thus demonstrating uptake specificity. Weekly changes in the vessel-wall area closely paralleled and correlated with RP782 uptake (Spearman r=0.95, P=0.001).
conclusionsInjury-induced MMP activation in the vessel wall can be detected by RP782 microSPECT/CT imaging in vivo. RP782 uptake tracks the hyperplastic process in vascular remodeling and provides an opportunity to track the remodeling process in vivo.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.