ArticleAntimicrobial agents and chemotherapy2009
High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals.
Article in Antimicrobial agents and chemotherapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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70 citing papers in PubMed.
- Plasmid-Mediated Quinolone Resistance Genes inVeterinary sciences · 2026Article
- Antimicrobial resistance of pet-derived bacteria in China, 2000-2020.Antimicrobial agents and chemotherapy · 2025Review
- Prevalence and characterization of quinolone resistance and integrons in clinical Gram-negative isolates from Gaza strip, Palestine.Molecular biology reports · 2024Article
- The rate of frequent co-existence of plasmid-mediated quinolone resistance (PMQR) and extended-spectrum β-lactamase (ESBL) genes inFood science and biotechnology · 2022Article
- Risk factors for third-generation cephalosporin-resistant and extended-spectrum β-lactamase-producing Escherichia coli carriage in domestic animals of semirural parishes east of Quito, Ecuador.PLOS global public health · 2022Article
- Molecular antibiotic resistance mechanisms and co-transmission of theFrontiers in microbiology · 2022Article
- Antimicrobial resistance patterns among differentSaudi journal of biological sciences · 2021Article
- Global prevalence and molecular characterization of extended-spectrum β-lactamase producing-One health (Amsterdam, Netherlands) · 2021Article
- Genetic diversity and co-prevalence of ESBLs and PMQR genes among plasmid-mediated AmpC β-lactamase-producing Klebsiella pneumoniae isolates causing urinary tract infection.The Journal of antibiotics · 2021Article
- Microbiota-associated risk factors for asymptomatic gut colonisation with multi-drug-resistant organisms in a Dutch nursing home.Genome medicine · 2021Article
- Diverse β-lactam antibiotic-resistant bacteria and microbial community in milk from mastitic cows.Applied microbiology and biotechnology · 2021Article
- Analysis of antibiotic resistance phenotypes and genes of Escherichia coli from healthy swine in Guizhou, China.The Onderstepoort journal of veterinary research · 2021Article
- Escherichia coli-associated granulomatous colitis in dogs treated according to antimicrobial susceptibility profiling.Journal of veterinary internal medicine · 2021Article
- Carbapenemase Production and Epidemiological Characteristics of Carbapenem-ResistantFrontiers in cellular and infection microbiology · 2021Article
- An Outbreak of Carbapenem-ResistantFrontiers in cellular and infection microbiology · 2021Article
- Occurrence of plasmid mediated fluoroquinolone resistance genes amongst enteric bacteria isolated from human and animal sources in Delta State, Nigeria.AIMS microbiology · 2021Article
- Multidrug-Resistant CTX-M and CMY-2 ProducingMicrobial drug resistance (Larchmont, N.Y.) · 2020Article
- Multidrug-Resistant ESBL/AmpC-ProducingAnimals : an open access journal from MDPI · 2020Article
- Extended-Spectrum Beta-Lactamase-ProducingFrontiers in public health · 2020Article
- AnAIMS microbiology · 2020Review
10 more citing papers are in PubMed but not listed here.
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Abstract
Three kinds of plasmid-mediated quinolone resistance (PMQR) determinants have been discovered and have been shown to be widely distributed among clinical isolates: qnr genes, aac(6')-Ib-cr, and qepA. Few data on the prevalence of these determinants in strains from animals are available. The presence of PMQR genes in isolates from animals was determined by PCR amplification and DNA sequencing. The production of extended-spectrum beta-lactamases (ESBLs) and AmpC beta-lactamases in the strains was detected, and their genotypes were determined. The genetic environment of PMQR determinants in selected plasmids was analyzed. All samples of ceftiofur-resistant (MICs > or = 8 microg/ml) isolates of the family Enterobacteriaceae were selected from 36 companion animals and 65 food-producing animals in Guangdong Province, China, between November 2003 and April 2007, including 89 Escherichia coli isolates, 9 Klebsiella pneumoniae isolates, and isolates of three other genera. A total of 68.3% (69/101) of the isolates produced ESBLs and/or AmpC beta-lactamases, mainly those of the CTX-M and CMY types. Of the 101 strains, PMQR determinants were present in 35 (34.7%) isolates, with qnr, aac(6')-Ib-cr, and qepA detected alone or in combination in 8 (7.9%), 19 (18.8%), and 16 (15.8%) strains, respectively. The qnr genes detected included one qnrB4 gene, four qnrB6 genes, and three qnrS1 genes. Five strains were positive for both aac(6')-Ib-cr and qepA, while one strain was positive for qnrS1, aac(6')-Ib-cr, and qepA. qnrB6 was flanked by two copies of ISCR1 with an intervening dfr gene downstream and sul1 and qacEDelta1 genes upstream. In another plasmid, aac(6')-Ib-cr followed intI1 and arr-3 was downstream. PMQR determinants are highly prevalent in ceftiofur-resistant Enterobacteriaceae strains isolated from animals in China. This is the first report of the occurrence of PMQR determinants among isolates from companion animals.
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