ArticleInfection and immunity2009
Identification of meningococcal genes necessary for colonization of human upper airway tissue.
Article in Infection and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Sustained salivary IgG but short-lived IgA responses following primary and booster MenACWY-TT vaccination in older adults.Human vaccines & immunotherapeutics · 2026Trial
- Zap the clap with DNA: a novel microbicide for preventingAntimicrobial agents and chemotherapy · 2024Article
- Type IV pilus retraction is required formBio · 2024Article
- Neisseria genes required for persistence identified via in vivo screening of a transposon mutant library.PLoS pathogens · 2022Article
- Interactions and Signal Transduction Pathways Involved during Central Nervous System Entry byInternational journal of molecular sciences · 2020Review
- Altering theBiochemistry · 2020Article
- Article
- PacBio Amplicon Sequencing Method To Measure Pilin Antigenic Variation Frequencies of Neisseria gonorrhoeae.mSphere · 2019Article
- UnravelingF1000Research · 2017Review
- Neisseria cinerea isolates can adhere to human epithelial cells by type IV pilus-independent mechanisms.Microbiology (Reading, England) · 2016Article
- Slam is an outer membrane protein that is required for the surface display of lipidated virulence factors in Neisseria.Nature microbiology · 2016Article
- Sigma factor RpoN (σ54) regulates pilE transcription in commensal Neisseria elongata.Molecular microbiology · 2013Article
- Identification of genes involved in Neisseria meningitidis colonization.Infection and immunity · 2013Article
- Neisseria conserved protein DMP19 is a DNA mimic protein that prevents DNA binding to a hypothetical nitrogen-response transcription factor.Nucleic acids research · 2012Article
- Interrogation of global mutagenesis data with a genome scale model of Neisseria meningitidis to assess gene fitness in vitro and in sera.Genome biology · 2011Article
- Focusing homologous recombination: pilin antigenic variation in the pathogenic Neisseria.Molecular microbiology · 2011Review
- Cooperative role for tetraspanins in adhesin-mediated attachment of bacterial species to human epithelial cells.Infection and immunity · 2011Article
- Article
- Human airway epithelial cell responses to Neisseria lactamica and purified porin via Toll-like receptor 2-dependent signaling.Infection and immunity · 2010Article
- Transcellular passage of Neisseria meningitidis across a polarized respiratory epithelium.Infection and immunity · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Neisseria meningitidis is an exclusively human pathogen that has evolved primarily to colonize the nasopharynx rather than to cause systemic disease. Colonization is the most frequent outcome following meningococcal infection and a prerequisite for invasive disease. The mechanism of colonization involves attachment of the organism to epithelial cells via bacterial type IV pili (Tfp), but subsequent events during colonization remain largely unknown. We analyzed 576 N. meningitidis mutants for their capacity to colonize human nasopharyngeal tissue in an organ culture model to identify bacterial genes required for colonization. Eight colonization-defective mutants were isolated. Two mutants were unable to express Tfp and were defective for adhesion to epithelial cells, which is likely to be the basis of their attenuation in nasopharyngeal tissue. Three other mutants are predicted to have lost previously uncharacterized surface molecules, while the remaining mutants have transposon insertions in genes of unknown function. We have identified novel meningococcal colonization factors, and this should provide insights into the survival of this important pathogen in its natural habitat.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.