ArticleInfection and immunity2009
The cytoplasmic domain of anthrax toxin receptor 1 affects binding of the protective antigen.
Article in Infection and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- ANTXR1 deficiency promotes fibroblast senescence: implications for GAPO syndrome as a progeroid disorder.Scientific reports · 2024Article
- The role of anthrax toxin protein receptor 1 as a new mechanosensor molecule and its mechanotransduction in BMSCs under hydrostatic pressure.Scientific reports · 2019Article
- Converging physiological roles of the anthrax toxin receptors.F1000Research · 2019Review
- TEM8 functions as a receptor for uPA and mediates uPA-stimulated EGFR phosphorylation.Cell communication and signaling : CCS · 2018Article
- Cell autonomous ANTXR1-mediated regulation of extracellular matrix components in primary fibroblasts.Matrix biology : journal of the International Society for Matrix Biology · 2017Article
- Bacillus cereus Certhrax ADP-ribosylates vinculin to disrupt focal adhesion complexes and cell adhesion.The Journal of biological chemistry · 2014Article
- A protective antigen mutation increases the pH threshold of anthrax toxin receptor 2-mediated pore formation.Biochemistry · 2014Article
- Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Binding of filamentous actin to anthrax toxin receptor 1 decreases its association with protective antigen.Biochemistry · 2012Article
- Review
- The dark sides of capillary morphogenesis gene 2.The EMBO journal · 2012Review
- Anthrax toxin protective antigen--insights into molecular switching from prepore to pore.Protein science : a publication of the Protein Society · 2012Review
- Broad expression analysis of human ANTXR1/TEM8 transcripts reveals differential expression and novel splizce variants.PloS one · 2012Article
- Article
- Targeting the anthrax receptors, TEM-8 and CMG-2, for anti-angiogenic therapy.Frontiers in bioscience (Landmark edition) · 2011Review
- The cell surface structure of tumor endothelial marker 8 (TEM8) is regulated by the actin cytoskeleton.Biochimica et biophysica acta · 2011Article
- Anthrax toxin receptor 1/tumor endothelial marker 8: mutation of conserved inserted domain residues overrides cytosolic control of protective antigen binding.Biochemistry · 2010Article
- Endocytosis of the anthrax toxin is mediated by clathrin, actin and unconventional adaptors.PLoS pathogens · 2010Article
- Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm.The Journal of biological chemistry · 2010Article
- Receptors of anthrax toxin and cell entry.Molecular aspects of medicine · 2009Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The protective antigen (PA) component of anthrax toxin binds the I domain of the receptor ANTXR1. Integrin I domains convert between open and closed conformations that bind ligand with high and low affinities, respectively; this process is regulated by signaling from the cytoplasmic domains. To assess whether intracellular signals might influence the interaction between ANTXR1 and PA, we compared two splice variants of ANTXR1 that differ only in their cytoplasmic domains. We found that cells expressing ANTXR1 splice variant 1 (ANTXR1-sv1) bound markedly less PA than did cells expressing a similar level of the shorter splice variant ANTXR1-sv2. ANTXR1-sv1 but not ANTXR1-sv2 associated with the actin cytoskeleton, although disruption of the cytoskeleton did not affect binding of ANTXR-sv1 to PA. Introduction of a cytoplasmic domain missense mutation found in the related receptor ANTXR2 in a patient with juvenile hyaline fibromatosis impaired actin association and increased binding of PA to ANTXR1-sv1. These results suggest that ANTXR1 has two affinity states that may be modulated by cytoplasmic signals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.