ArticleThe Journal of physiology2008
Voltage-dependent gating of NR1/2B NMDA receptors.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- NEURONpyxl: fast, flexible, Python-integrated simulation of biophysical neural networks with complex plastic synapses.Frontiers in computational neuroscience · 2026Article
- Neuron-Glia Interactions and Brain Circuits.Advances in experimental medicine and biology · 2022Article
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- Interplay between Gating and Block of Ligand-Gated Ion Channels.Brain sciences · 2020Review
- Astrocyte-mediated spike-timing-dependent long-term depression modulates synaptic properties in the developing cortex.PLoS computational biology · 2020Article
- Effects of Acute Normobaric Hypoxia on Memory Interference.Brain sciences · 2019Article
- Disease-associated missense mutations in GluN2B subunit alter NMDA receptor ligand binding and ion channel properties.Nature communications · 2018Article
- Molecular bases of NMDA receptor subtype-dependent properties.The Journal of physiology · 2015Review
- Indistinguishable synaptic pharmacodynamics of the N-methyl-D-aspartate receptor channel blockers memantine and ketamine.Molecular pharmacology · 2013Article
- Effect of exercise training on long-term potentiation and NMDA receptor channels in rats with cerebral infarction.Experimental and therapeutic medicine · 2013Article
- A fast model of voltage-dependent NMDA receptors.Journal of computational neuroscience · 2013Article
- Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Mechanistic and structural determinants of NMDA receptor voltage-dependent gating and slow Mg2+ unblock.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Noncompetitive, voltage-dependent NMDA receptor antagonism by hydrophobic anions.Molecular pharmacology · 2013Article
- Selective Pharmacological Modulation of Pyramidal Neurons and Interneurons in the CA1 Region of the Rat Hippocampus.Frontiers in pharmacology · 2013Article
- Formaldehyde increases intracellular calcium concentration in primary cultured hippocampal neurons partly through NMDA receptors and T-type calcium channels.Neuroscience bulletin · 2012Article
- Backpropagating action potentials enable detection of extrasynaptic glutamate by NMDA receptors.Cell reports · 2012Article
- NMDA receptors with incomplete Mg²⁺ block enable low-frequency transmission through the cerebellar cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Lipid rafts control P2X3 receptor distribution and function in trigeminal sensory neurons of a transgenic migraine mouse model.Molecular pain · 2011Article
- Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Ligand-gated ion channels are activated by agonist binding, but may also be modulated by membrane voltage. N-Methyl-d-aspartate receptors (NMDARs) exhibit especially strong voltage dependence due to channel block by external Mg(2+) (Mg(o)(2+)). Here we demonstrate that activity of NMDARs composed of NR1 and NR2B subunits (NR1/2B receptors) is enhanced by depolarization even in 0 Mg(o)(2+), causing slow current relaxations in response to rapid voltage changes. We present a kinetic model of receptor activation that incorporates voltage-dependent gating-associated NR2B subunit conformational changes. The model accurately reproduces current relaxations during depolarizations and subsequent repolarizations in 0 Mg(o)(2+). Model simulations in physiological Mg(o)(2+) concentrations show that voltage-dependent receptor gating also underlies the slow component of Mg(o)(2+) unblock, a phenomenon that previously was shown to influence Mg(o)(2+) unblock kinetics during dendritic spikes. We propose that voltage-dependent gating of NR1/2B receptors confers enhanced voltage and time dependence on NMDAR-mediated signalling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.