Trial reportThe Journal of physiology2008
Modulation of recurrent inhibition from knee extensors to ankle motoneurones during human walking.
Trial report in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- Kinetics and Muscle Activity Patterns during Unweighting and Reloading Transition Phases in Running.PloS one · 2016Trial
- Article
- Heteronymous feedback from quadriceps onto soleus is influenced by limb loading and task context.Scientific reports · 2025Article
- Heteronymous feedback from quadriceps onto soleus in stroke survivors.Journal of neuroengineering and rehabilitation · 2025Article
- Reduced inhibition from quadriceps onto soleus after acute quadriceps fatigue suggests Golgi tendon organ contribution to heteronymous inhibition.The European journal of neuroscience · 2024Article
- Heteronymous feedback from quadriceps onto soleus in stroke survivors.Research square · 2024Article
- Differential effect of heteronymous feedback from femoral nerve and quadriceps muscle stimulation onto soleus H-reflex.PloS one · 2023Article
- Intra-limb modulations of posterior root-muscle reflexes evoked from the lower-limb muscles during isometric voluntary contractions.Experimental brain research · 2021Article
- Neurophysiological Changes After Paired Brain and Spinal Cord Stimulation Coupled With Locomotor Training in Human Spinal Cord Injury.Frontiers in neurology · 2021Article
- Spinal Control of Locomotion: Individual Neurons, Their Circuits and Functions.Frontiers in physiology · 2018Review
- Corticospinal and reciprocal inhibition actions on human soleus motoneuron activity during standing and walking.Physiological reports · 2015Article
- Modulation of motoneuron firing by recurrent inhibition in the adult rat in vivo.Journal of neurophysiology · 2014Article
- Joint-specific changes in locomotor complexity in the absence of muscle atrophy following incomplete spinal cord injury.Journal of neuroengineering and rehabilitation · 2013Article
- Functional reorganization of soleus H-reflex modulation during stepping after robotic-assisted step training in people with complete and incomplete spinal cord injury.Experimental brain research · 2013Article
- Targeted deletion of the mouse α2 nicotinic acetylcholine receptor subunit gene (Chrna2) potentiates nicotine-modulated behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Beyond muscular effects: depression of spinal recurrent inhibition after botulinum neurotoxin A.The Journal of physiology · 2013Article
- Seeking functions for spinal recurrent inhibition.The Journal of physiology · 2008Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neural control for muscle coordination during human locomotion involves spinal and supraspinal networks, but little is known about the exact mechanisms implicated. The present study focused on modulation of heteronymous recurrent inhibition from knee extensors to ankle motoneurones at different times in the gait cycle, when quadriceps (Quad) muscle activity overlaps that in tibialis anterior (TA) and soleus (Sol). The effects of femoral nerve stimulation on ankle motoneurones were investigated during treadmill walking and during tonic co-contraction of Quad and TA/Sol while standing. Recurrent inhibition of TA motoneurones depended on the level of background EMG, and was similar during walking and standing for matched background EMG levels. On the other hand, recurrent inhibition in Sol was reduced in early stance, with respect to standing, and enhanced in late stance. Reduced inhibition in Sol was also observed when Quad was coactivated with TA around the time of heel contact, compared to standing at matched background EMG levels in the two muscles. The modulation of recurrent inhibition of Sol during walking might reflect central and/or peripheral control of the Renshaw cells. These modulations could be implicated in the transition phases, from swing to stance to assist Sol activation during the stance phase, and from stance to swing, for its deactivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.