ArticleCalcified tissue international1991
Structural changes of the periosteocytic area in Vipera aspis (L.) (Ophidia, Viperidae) bone tissue in various physiological conditions.
Article in Calcified tissue international, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 37 citations in OpenAlex.
- Cellular, bone-like tissue in the bucklers and thorns of the thornback rayProceedings. Biological sciences · 2025Article
- Osteocyte Remodeling of the Lacunar-Canalicular System: What's in a Name?Current osteoporosis reports · 2023Review
- Deletion of Orai1 leads to bone loss aggravated with aging and impairs function of osteoblast lineage cells.Bone reports · 2018Article
- The osteocyte: an endocrine cell ... and more.Endocrine reviews · 2013Review
- Review
- Osteocytic osteolysis: time for a second look?BoneKEy reports · 2012Review
- Article
- Mammalian hibernation as a model of disuse osteoporosis: the effects of physical inactivity on bone metabolism, structure, and strength.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Review
- The evolutionary origins of maternal calcium and bone metabolism during lactation.Journal of mammary gland biology and neoplasia · 2002Review
- Osteocytes, strain detection, bone modeling and remodeling.Calcified tissue international · 1993Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microradiographs of ribs and vertebrae of the snake Vipera aspis, over an annual cycle, show a significant enlargement of the osteocytic lacunae in the winter months and, for the breeding females, during the period of embryo development. This enlargement is due to resorption of bone substance (periosteocytic osteolysis). The objection that such morphological findings could as well be explained by the formation of new, larger osteocytes derived from recent osteoblasts does not apply to the present animal model. No internal bone remodelling occurs during the annual seasonal cycle and therefore no new osteoblasts would have differentiated to osteocytes in the interior of the bone. In the vertebrae, an additional process is indicated as an area of decreased mineral density, termed demineralization halo, around the periosteocytic lacunae. An electron microscopy study suggests that this process of demineralization is not the first stage of periosteocytic resorption, but an additional process of demineralization. Thus, both osteolysis and demineralization halos in the perilacunar osteocytic region of the bone tissue represent reversible biological processes mediated by the osteocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.