ArticleCalcified tissue international1991
Normal bone particles are preferentially resorbed in the presence of osteocalcin-deficient bone particles in vivo.
Article in Calcified tissue international, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 55 citations in OpenAlex.
- Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women.The Journal of clinical investigation · 1993Trial
- Type 2 diabetic mellitus related osteoporosis: focusing on ferroptosis.Journal of translational medicine · 2024Review
- Comparative proteomic analysis of dental cementum from deciduous and permanent teeth.Journal of periodontal research · 2021Article
- Effect of Qing'e Decoction on Leptin/Leptin Receptor and Bone Metabolism in Naturally Aging Rats.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Bone Matrix Levels of Dickkopf and Sclerostin are Positively Correlated with Bone Mass and Strength in Postmenopausal Osteoporosis.International journal of molecular sciences · 2019Article
- Biomimetic matrices for rapidly forming mineralized bone tissue based on stem cell-mediated osteogenesis.Scientific reports · 2018Article
- An overview of osteocalcin progress.Journal of bone and mineral metabolism · 2016Review
- The (1)H NMR structure of bovine Pb(2+)-osteocalcin and implications for lead toxicity.Biochimica et biophysica acta · 2008Article
- The three-dimensional structure of bovine calcium ion-bound osteocalcin using 1H NMR spectroscopy.Biochemistry · 2003Article
- Development of the osteoblast phenotype: molecular mechanisms mediating osteoblast growth and differentiation.The Iowa orthopaedic journal · 1995Review
- Osteocalcin induces chemotaxis, secretion of matrix proteins, and calcium-mediated intracellular signaling in human osteoclast-like cells.The Journal of cell biology · 1994Article
- Age- and gender-related changes in the distribution of osteocalcin in the extracellular matrix of normal male and female bone. Possible involvement of osteocalcin in bone remodeling.The Journal of clinical investigation · 1994Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In an in vivo model of osteoclastic bone resorption, we previously showed that osteocalcin-deficient bone particles (BPs), derived from warfarin-treated rats, were resorbed 50% as well as normal BPs and that they recruited fewer osteoclastic cells with decreased tartrate-resistant acid phosphatase (TRAP) activity. In order to determine the specificity of the resorption response, we evaluated the fate of implanted mixtures of normal and osteocalcin-deficient BPs. Normal and warfarin-treated donor rats were prelabeled in vivo with oxytetracycline to permit identification of BPs from either source. Normal, osteocalcin-deficient, and 50:50 mixtures of BPs (either labeled or unlabeled) were implanted into normal rats and recovered 12 days later for enzymatic (TRAP) and nondecalcified histomorphometric analyses. The incorporated oxytetracycline had no significant effect on resorption of bone particles. The recovered osteocalcin-deficient BPs were surrounded by fewer osteoclastic cells, were resorbed less, and contained less extractable TRAP activity than normal BPs. In mixed BP implants with normal and osteocalcin-deficient BPs, each type of bone particle elicited the same tissue response as when implanted separately. Remarkably, the different particles evoked dissimilar osteoclastic responses and were resorbed to different extents, even when adjacent within the same implant. These data suggest that osteocalcin may act as a substrate signal for resorption and that osteocalcin in the normal BPs does not influence the cellular response to adjacent osteocalcin-deficient BPs.
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