ArticleWorld journal of gastroenterology2008
Distinct expression patterns in hepatitis B virus- and hepatitis C virus-infected hepatocellular carcinoma.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Deregulation of ribosomal proteins in human cancers.Bioscience reports · 2021Review
- Review
- Genetic Biomarkers For Hepatocellular Carcinoma In The Era Of Precision Medicine.Journal of hepatocellular carcinoma · 2019Review
- Article
- 5-Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing β-catenin.Molecular oncology · 2016Article
- miRNA-7/21/107 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin.Oncotarget · 2015Article
- Growth rate of early-stage hepatocellular carcinoma in patients with chronic liver disease.Clinical and molecular hepatology · 2015Article
- Recurrence-associated pathways in hepatitis B virus-positive hepatocellular carcinoma.BMC genomics · 2015Article
- Management of hepatocellular carcinoma: Predictive value of immunohistochemical markers for postoperative survival.World journal of hepatology · 2015Review
- Quantitative Proteomics Analysis of the Hepatitis C Virus Replicon High-Permissive and Low-Permissive Cell Lines.PloS one · 2015Article
- IGF-Binding Protein 2 - Oncogene or Tumor Suppressor?Frontiers in endocrinology · 2015Review
- Genomic profiling of collaborative cross founder mice infected with respiratory viruses reveals novel transcripts and infection-related strain-specific gene and isoform expression.G3 (Bethesda, Md.) · 2014Article
- Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma.Nature reviews. Cancer · 2013Review
- HBV induced HCC: major risk factors from genetic to molecular level.BioMed research international · 2013Review
- HCMV targets the metabolic stress response through activation of AMPK whose activity is important for viral replication.PLoS pathogens · 2012Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo identify biomarkers indicating virus-specific hepatocarcinogenic process, differential mRNA expression in 32 patients with hepatitis B virus (HBV)-/hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC) were investigated by means of cDNA microarrays comprising of 886 genes.
methodsThirty two HCC patients were divided into two groups based on viral markers: hepatitis B virus positive and HCV positive. The expression profiles of 32 pairs of specimens (tumorous and surrounding non-tumorous liver tissues), consisting of 886 genes were analyzed.
resultsSeven up-regulated genes in HBV-associated HCC comprised genes involved in protein synthesis (RPS5), cytoskeletal organization (KRT8), apoptosis related genes (CFLAR), transport (ATP5F1), cell membrane receptor related genes (IGFBP2), signal transduction or transcription related genes (MAP3K5), and metastasis-related genes (MMP9). The up-regulated genes in HCV-infected group included 4 genes: VIM (cell structure), ACTB (cell structure), GAPD (glycolysis) and CD58 (cell adhesion). The expression patterns of the 11 genes, identified by cDNA microarray, were confirmed by quantitative RT-PCR in 32 specimens.
conclusionThe patterns of all identified genes were classified based on the viral factor involved in HBV- and HCV-associated HCC. Our results strongly suggest that the pattern of gene expression in HCC is closely associated with the etiologic factor. The present study indicates that HBV and HCV cause hepatocarcinogenesis by different mechanisms, and provide novel tools for the diagnosis and treatment of HBV- and HCV-associated HCC.
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