ArticleWorld journal of gastroenterology2008
Dietary glycine blunts liver injury after bile duct ligation in rats.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Glycine alleviated diquat-induced hepatic injury via inhibiting ferroptosis in weaned piglets.Animal bioscience · 2022Article
- The role of glycine in regulated cell death.Cellular and molecular life sciences : CMLS · 2016Review
- Repair-related activation of hedgehog signaling in stromal cells promotes intrahepatic hypothyroidism.Endocrinology · 2014Article
- Some mechanisms of the protective effect of ischemic preconditioning on rat liver ischemia-reperfusion injury.International journal of general medicine · 2014Article
- Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis.Journal of hepatology · 2013Article
- Ischemia/Reperfusion injury in liver surgery and transplantation: pathophysiology.HPB surgery : a world journal of hepatic, pancreatic and biliary surgery · 2012Article
- Glycine and glycine receptor signalling in non-neuronal cells.Frontiers in molecular neuroscience · 2009Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effects of (dietary) glycine against oxidant-induced injury caused by bile duct ligation (BDL).
methodsEither a diet containing 5% glycine or a standard diet was fed to male Sprague-Dawley (SD) rats. Three days later, BDL or sham-operation was performed. Rats were sacrificed 1 to 3 d after BDL. The influence of deoxycholic acid (DCA) in the presence or absence of glycine on liver cells was determined by measurement of calcium and chloride influx in cultivated Kupffer cells and lactate dehydrogenase (LDH) activity was determined in the supernatant of cultivated hepatocytes.
resultsSerum alanine transaminase levels increased to about 600 U/L 1 d after BDL. However, enzyme release was blunted by about two third in rats receiving glycine. Release of the alkaline phosphatase and aspartate aminotransferase was also blocked significantly in the group fed glycine. Focal necrosis was observed 2 d after BDL. Glycine partially blocked the histopathological changes. Incubation of Kupffer cells with DCA led to increased intracellular calcium that could be blocked by incubation with glycine. However, systemic blockage of Kupffer cells with gadolinium chloride had no effects on transaminase release. Incubation of isolated hepatocytes with DCA led to a significant release of LDH after 4 h. This release was largely blocked when incubation with glycine was performed.
conclusionThese data indicate that glycine significantly decreased liver injury, most likely by a direct effect on hepatocytes. Kupffer cells do not appear to play an important role in the pathological changes caused by cholestasis.
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