Evidence map›Paper›PMID 18931862›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2009

Associations between quality of life, fatigue, and cytokine levels in patients aged 50+ with acute myeloid leukemia.

Abbas H Panju, Ali Danesh, Mark D Minden, David J Kelvin, Shabbir M H Alibhai

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In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. A novel decision aid for acute myeloid leukemia: a feasibility and preliminary efficacy trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Article
  8. Article
  9. Observational
  10. Article
  11. Article
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  13. Article
  14. Twist as a new prognostic marker in hematological malignancies.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2016
    Review
  15. Article
  16. Incorporating biomarkers into cancer and aging research.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2014
    Review
  17. Adult Acute Myeloid Leukemia Long-term Survivors.Journal of leukemia (Los Angeles, Calif.) · 2014
    Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Abbas H PanjuDepartment of Medicine, University Health Network, Toronto General Hospital, 200 Elizabeth Street (EN14-214), Toronto, Ontario M5G 2C4, Canada.
Ali Danesh
Mark D Minden
David J Kelvin
Shabbir M H Alibhai
Toronto General Hospital · CAUniversity Health Network · CAPrincess Margaret Cancer Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

goals of workQuality of life (QOL) is significantly impaired in patients with acute myeloid leukemia (AML), and fatigue is the most common and disabling symptom; effective treatment measures have yet to be found. Cytokines, biomarkers of inflammation, may moderate both health outcomes, but published data are limited. We looked at the role of cytokines in modulating QOL and fatigue in an older AML population. PATIENTS AND

methodsWe recruited 34 English-speaking patients (23 men, 11 women) aged 50 or older with AML within 1 year of diagnosis. QOL and fatigue were assessed with validated questionnaires. Blood was simultaneously drawn for quantitative measurement of a 13-cytokine panel. Repeat measurements were done 4-6 weeks later (n = 28 patients). Spearman correlations between health measures and cytokine levels were examined at baseline, as were changes in variables between time points. A potentially clinically important correlation was defined as an r > or = 0.30.

resultsAt baseline, potentially clinically important correlations were noted between global QOL and interferon (IFN)-gamma (r = -0.376, p = 0.031), interleukin (IL)-2 (r = -0.340, p = 0.053), IL-5 (r = -0.368, p = 0.035), IL-8 (r = -0.312, p = 0.077), and TNF-alpha (r = -0.326, p = 0.064). A similar correlation was observed between IL-6 and fatigue (r = 0.332, p = 0.059). Between time points, there were no potentially important correlations between changes in global QOL and any cytokine. However, potentially important correlations with fatigue were seen with both IL-5 (r = 0.344, p = 0.073) and IL-10 (r = 0.326, p = 0.091) between time points.

conclusionsThese preliminary data provide support for a larger controlled study of cytokines, fatigue, and QOL in patients with AML.

Indexed as

Quality of LifeAgedAged, 80 and overBiomarkersCytokinesFatigueFemaleHumansLeukemia, Myeloid, AcuteMaleMiddle AgedPilot ProjectsStatistics, NonparametricSurveys and QuestionnairesBiomarkersCytokines

Identifiers

PMID18931862
OpenAlexW2083158296

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.