ArticlePediatric radiology2008
Magnetic resonance imaging of miliary tuberculosis of the central nervous system in children with tuberculous meningitis.
Article in Pediatric radiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- The etiological spectrum of miliary brain lesions: A systematic review of published cases and case series.The neuroradiology journal · 2024Pooled it
- A systemic review of tuberculosis with HIV coinfection in children.Pediatric radiology · 2017Pooled it
- Pediatric Tuberculosis: Unraveling Immunity, Clinical Complexities, and Resource-Driven Disparities in the Pursuit of Prevention.Vaccines · 2026Review
- Intracranial manifestations of central nervous system tuberculosis in children.Pediatric radiology · 2025Review
- Magnetic resonance imaging findings in central nervous system tuberculosis: A pictorial review.Heliyon · 2024Review
- Diagnostic validity of MRI for central nervous system tuberculosis: protocol for a systematic review and meta-analysis.BMJ open · 2023Article
- Review of Pediatric Tuberculosis in the Aftermath of COVID-19.Clinics and practice · 2022Review
- Cerebral Infarction and Evan's Ratio on MRI Affect the Severity and Prognosis of Tuberculosis Meningitis Patients.Diagnostics (Basel, Switzerland) · 2022Article
- Case Report: Unusual High-Grade Diffuse Leptomeningeal Glioneuronal Tumor Mimicking Tuberculous Meningitis in a Child From an Endemic Region.Frontiers in pediatrics · 2021Article
- Challenges in the diagnosis of tuberculous meningitis.Journal of clinical tuberculosis and other mycobacterial diseases · 2020Article
- Extensive perivascular dissemination of cerebral miliary tuberculomas: a case report and review of the literature.Acta radiologica open · 2018Article
- Tuberculosis in Children.Pediatric clinics of North America · 2017Review
- Magnetic resonance imaging of sellar and juxtasellar abnormalities in the paediatric population: an imaging review.Insights into imaging · 2015Article
- Acute myelopathy or cauda equina syndrome in HIV-positive adults in a tuberculosis endemic setting: MRI, clinical, and pathologic findings.AJNR. American journal of neuroradiology · 2014Article
- Central nervous system tuberculosis in non-HIV-positive children: a single-center, 6 year experience.La Radiologia medica · 2012Article
- MRI findings in children with tuberculous meningitis: a comparison of HIV-infected and non-infected patients.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTuberculous meningitis (TBM) is closely associated with miliary tuberculosis and a pathogenetic relationship is suspected, although it has been proposed that the two processes are unrelated.
objectiveTo describe miliary tuberculosis of the central nervous system (CNS) on MRI in children with TBM. MATERIALS AND
methodsA retrospective descriptive study of 32 paediatric TBM patients referred for MRI. The presence of miliary nodules in the CNS was recorded. Lesions were categorized according to their distribution, enhancement pattern, size and signal characteristics.
resultsA miliary distribution of nodules was present in 88% of patients. All patients with a miliary distribution had leptomeningeal nodules and 18% of these patients had deep parenchymal nodules in addition. At least one tuberculoma with central T2 hypointensity was identified in 39% of patients.
conclusionThe high prevalence of miliary leptomeningeal nodules in the CNS of children with TBM is significant because it points to a pathogenetic relationship that has long been suspected on epidemiological grounds. Our findings challenge the concept that miliary tuberculosis is only an incidental finding in TBM patients and suggest that it plays an integral part in the pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.