ArticlePsychopharmacology2009
Role of beta2-containing nicotinic acetylcholine receptors in auditory event-related potentials.
Article in Psychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- P50 amplitude reduction: a nicotinic receptor-mediated deficit in first-degree relatives of schizophrenia patients.Psychopharmacology · 2012Trial
- Mouse model predicts effects of smoking and varenicline on event-related potentials in humans.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2010Trial
- Anesthesia and analgesia for experimental craniotomy in mice and rats: a systematic scoping review comparing the years 2009 and 2019.Frontiers in neuroscience · 2023Article
- Animal Models of Psychosis: Current State and Future Directions.Current behavioral neuroscience reports · 2014Article
- Arousal and attention re-orienting in autism spectrum disorders: evidence from auditory event-related potentials.Frontiers in human neuroscience · 2014Article
- Animal models and measures of perceptual processing in schizophrenia.Neuroscience and biobehavioral reviews · 2013Review
- Electroencephalographic and early communicative abnormalities in Brattleboro rats.Physiological reports · 2013Article
- Electrophysiological and behavioral responses to ketamine in mice with reduced Akt1 expression.Psychopharmacology · 2013Article
- Nicotine receptor subtype-specific effects on auditory evoked oscillations and potentials.PloS one · 2012Article
- The smoking cessation drug varenicline improves deficient P20-N40 inhibition in DBA/2 mice.Pharmacology, biochemistry, and behavior · 2011Article
- Ondansetron results in improved auditory gating in DBA/2 mice through a cholinergic mechanism.Brain research · 2009Article
- Event-related oscillations as risk markers in genetic mouse models of high alcohol preference.Neuroscience · 2009Article
- Event-related oscillations in mice: effects of stimulus characteristics.Journal of neuroscience methods · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleNicotine improves sensory processing in schizophrenic individuals, as measured by changes in auditory event-related potentials (ERPs). Nicotine administration also alters ERPs in mice by increasing the amplitude and gating of the P20 ERP component while decreasing the amplitude of the N40 ERP component. Less is known about the role of specific nicotinic acetylcholine receptor (nAChR) subtypes.
objectivesIn this study, we examined whether nAChRs containing the beta2 subunit contribute to nicotine's effects on auditory ERPs. MATERIALS AND
methodsWe tested the effect of nicotine in wild-type mice and mice lacking the beta2 nAChR subunit. Mice underwent stereotaxic implantation of stainless steel electrodes located in the CA3 region of the hippocampus, and 50 paired click stimuli were delivered during each drug condition.
resultsThere was no significant difference in P20 or N40 amplitude or gating between genotypes during the control condition, suggesting that beta2-containing receptors are not essential for the baseline auditory ERP response. Nicotine increased P20 amplitude and enhanced gating in wild-type and beta2 knockout mice, but only decreased N40 amplitude in wild-type mice. There was no effect of nicotine on N40 gating in either genotype.
conclusionsbeta2-containing receptors are necessary for nicotine's effects on the N40 component of the mouse auditory ERP. These results suggest that beta2-containing nAChRs modulate sensory processing and may serve as a therapeutic target in schizophrenic individuals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.