ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2009
Vertebral fractures in patients with chronic obstructive pulmonary disease: the EOLO Study.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- [Osteoporosis in pneumological diseases : Joint guideline of the Austrian Society for Bone and Mineral Research (ÖGKM) and the Austrian Society for Pneumology (ÖGP)].Wiener klinische Wochenschrift · 2021Guideline
- Mortality and vertebral fracture risk associated with long-term oral steroid use in patients with chronic obstructive pulmonary disease: A systemic review and meta-analysis.Chronic respiratory diseasePooled it
- Thoracic Kyphosis on Chest CT Scans Is Associated With Incident Vertebral Fractures in Smokers.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Trial
- Osteoporosis markers on low-dose lung cancer screening chest computed tomography scans predict all-cause mortality.European radiology · 2015Trial
- Association of hospital-initiated bone densitometry with hospitalization for fragility fracture at Lille University Hospital among adults with chronic obstructive pulmonary disease.Archives of osteoporosis · 2025Observational
- Chest CT-based automated vertebral fracture assessment using artificial intelligence and morphologic features.Medical physics · 2024Article
- Osteoporosis in Asthma and COPD.Indian journal of orthopaedics · 2023Review
- Osteoporosis and major fragility fractures (MOF) in sarcoidosis patients: association with disease severity.Aging clinical and experimental research · 2023Article
- The role of vitamin D in chronic obstructive pulmonary disease with pulmonary hypertension.Pulmonary circulation · 2023Article
- Bone fragility and sarcoidosis: An underestimated relationship.Frontiers in medicine · 2022Article
- The Influence of Restrictive Pulmonary Dysfunction on Osteoporotic Thoracic Vertebral Fractures.Asian spine journal · 2021Article
- Incidence of fractures among patients receiving medications for type 2 diabetes or chronic obstructive pulmonary disease and glucocorticoid users according to the National Claims Database in Japan.Archives of osteoporosis · 2021Article
- Muscle-Bone Crosstalk in Chronic Obstructive Pulmonary Disease.Frontiers in endocrinology · 2021Review
- Association between vertebral fractures and coronary artery calcification in current and former smokers in the ECLIPSE cohort.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- Vertebral bone attenuation in Hounsfield Units and prevalent vertebral fractures are associated with the short-term risk of vertebral fractures in current and ex-smokers with and without COPD: a 3-year chest CT follow-up study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- Association between airflow limitation severity and reduced bone mineral density in Japanese men.International journal of chronic obstructive pulmonary disease · 2019Article
- Diagnosis of vertebral deformities on chest CT and DXA compared to routine lateral thoracic spine X-ray.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema.PloS one · 2018Article
- Inflammatory diseases and bone fragility.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Review
- The Relationship of Bone Mineral Density in Men with Chronic Obstructive Pulmonary Disease Classified According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) Combined Chronic Obstructive Pulmonary Disease (COPD) Assessment System.Internal medicine (Tokyo, Japan) · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
summaryThis study aimed to evaluate the prevalence of vertebral fractures to investigate the determinants of vertebral fracture risk in patients with COPD. The risk of vertebral fractures is strictly related to the severity of the disease. The use of glucocorticoids and the presence of low values of quantitative ultrasound (QUS) may represent additional risk factors.
introductionChronic obstructive pulmonary disease (COPD) appears to be associated with osteoporosis. Our study aimed to evaluate the prevalence of vertebral fractures and to investigate the main determinants of vertebral fracture risk in patients with COPD.
methodsIn 3,030 ambulatory COPD patients (1,778 men and 1,262 women) aged 50 years or over, we evaluated: COPD severity, presence of vertebral fractures on lateral chest X-ray and bone status by using a quantitative ultrasound device.
resultsIn men there was a strong association between COPD severity and fractures (p < 0.001), conversely in women the association between COPD severity and fractures was at limit (p = 0.049). In men, but not in women, glucocorticoid treatment was significantly associated with vertebral fractures. The patients with high or moderate risk of osteoporosis presented an increased risk of vertebral fracture (OR 2.71; 95% CI 2.04-3.60 and OR 1.54; 95% CI 1.26-1.88, respectively). Logistic regression analysis showed that COPD severity and glucocorticoid treatment, both inhaled and oral, were associated with increased risk of vertebral fractures.
conclusionIn COPD patients the risk of vertebral fractures is strictly related to the severity of the disease. The use of glucocorticoids and reduced QUS at calcaneous may represent additional risk factors.
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