ArticleNature materials2008
Sustained release of a p38 inhibitor from non-inflammatory microspheres inhibits cardiac dysfunction.
Article in Nature materials, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed.
- Polyketal-conjugated tafluprost microparticles enable long-acting glaucoma therapy.Nature communications · 2026Article
- Hydrogels in cardiac tissue engineering: application and challenges.Molecular and cellular biochemistry · 2025Review
- Association of frailty index with incidence of chronic kidney disease: China Health and Retirement Longitudinal Study.European geriatric medicine · 2025Article
- Dynamic Release from Acetalated Dextran Nanoparticles for Precision Therapy of Inflammation.ACS applied bio materials · 2024Article
- Nanomaterial-Based Electrically Conductive Hydrogels for Cardiac Tissue Repair.International journal of nanomedicine · 2022Review
- Modular ketal-linked prodrugs and biomaterials enabled by organocatalytic transisopropenylation of alcohols.Nature communications · 2021Article
- Inflammation-responsive delivery systems for the treatment of chronic inflammatory diseases.Drug delivery and translational research · 2021Review
- Periadventitial Delivery of Simvastatin-Loaded Microparticles Attenuate Venous Neointimal Hyperplasia Associated With Arteriovenous Fistula.Journal of the American Heart Association · 2020Article
- Nanostructured Polymeric, Liposomal and Other Materials to Control the Drug Delivery for Cardiovascular Diseases.Pharmaceutics · 2020Review
- Bioresponsive drug delivery systems for the treatment of inflammatory diseases.Journal of controlled release : official journal of the Controlled Release Society · 2020Review
- Review
- A Bioinspired Scaffold with Anti-Inflammatory Magnesium Hydroxide and Decellularized Extracellular Matrix for Renal Tissue Regeneration.ACS central science · 2019Article
- Substituent Effects on the pH Sensitivity of Acetals and Ketals and Their Correlation with Encapsulation Stability in Polymeric Nanogels.Journal of the American Chemical Society · 2017Article
- Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNANature biomedical engineering · 2017Article
- Multifunctional folate receptor-targeting and pH-responsive nanocarriers loaded with methotrexate for treatment of rheumatoid arthritis.International journal of nanomedicine · 2017Article
- PLGA-PNIPAM Microspheres Loaded with the Gastrointestinal Nutrient NaB Ameliorate Cardiac Dysfunction by Activating Sirt3 in Acute Myocardial Infarction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2016Article
- Do p38 mitogen-activated protein kinase inhibitors have a future for the treatment of cardiovascular disease?Journal of thoracic disease · 2016Article
- Light-triggered chemical amplification to accelerate degradation and release from polymeric particles.Chemical communications (Cambridge, England) · 2015Article
- Modulation of p38 kinase by DUSP4 is important in regulating cardiovascular function under oxidative stress.Free radical biology & medicine · 2015Article
- Bioactive nanoparticles improve calcium handling in failing cardiac myocytes.Nanomedicine (London, England) · 2015Article
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8 authors.
Funding
Abstract
Cardiac dysfunction following acute myocardial infarction is a major cause of death in the world and there is a compelling need for new therapeutic strategies. In this report we demonstrate that a direct cardiac injection of drug-loaded microparticles, formulated from the polymer poly(cyclohexane-1,4-diylacetone dimethylene ketal) (PCADK), improves cardiac function following myocardial infarction. Drug-delivery vehicles have great potential to improve the treatment of cardiac dysfunction by sustaining high concentrations of therapeutics within the damaged myocardium. PCADK is unique among currently used polymers in drug delivery in that its hydrolysis generates neutral degradation products. We show here that PCADK causes minimal tissue inflammatory response, thus enabling PCADK for the treatment of inflammatory diseases, such as cardiac dysfunction. PCADK holds great promise for treating myocardial infarction and other inflammatory diseases given its neutral, biocompatible degradation products and its ability to deliver a wide range of therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.