Evidence map›Paper›PMID 18931483›Full record

ArticleCytogenetic and genome research2008

A 4,103 marker integrated physical and comparative map of the horse genome.

T Raudsepp, A Gustafson-Seabury, K Durkin, M L Wagner, G Goh, C M Seabury, C Brinkmeyer-Langford, E-J Lee, R Agarwala, E Stallknecht-Rice and 14 more

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Cytogenetic and genome research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
7.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Horse Clinical Cytogenetics: Recurrent Themes and Novel Findings.Animals : an open access journal from MDPI · 2021
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Applied equine genetics.Equine veterinary journal · 2014
    Review
  13. Article
  14. Advanced comparative cytogenetic analysis of X chromosomes in river buffalo, cattle, sheep, and human.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012
    Article
  15. High-resolution chromosome painting reveals the first genetic signature for the chiropteran suborder Pteropodiformes (Mammalia: Chiroptera).Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011
    Article
  16. Article
  17. Article
  18. Equine clinical genomics: A clinician's primer.Equine veterinary journal · 2010
    Review
  19. Article
  20. Whole-genome scan identifies quantitative trait loci for chronic pastern dermatitis in German draft horses.Mammalian genome : official journal of the International Mammalian Genome Society · 2010
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 13 institutions in 8 countries.

T RaudseppDepartment of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA. traudsepp@cvm.tamu.edu
A Gustafson-Seabury
K Durkin
M L Wagner
G Goh
C M Seabury
C Brinkmeyer-Langford
E-J Lee
R Agarwala
E Stallknecht-Rice
A A Schäffer
L C Skow
T Tozaki
H Yasue
M C T Penedo
L A Lyons
K A Khazanehdari
M M Binns
J N MacLeod
O Distl
G Guérin
T Leeb
J R Mickelson
B P Chowdhary
Mitchell Institute · USNational Institutes of Health · USTexas A&M University · USUniversity of California, Davis · USCentral Veterinary Research Laboratory · AEInstitute of Agrobiological Sciences · JPInstitut National de la Recherche Agronomique du Niger · NELaboratory of Racing Chemistry · JPUniversidad de Londres · MXUniversity of Bern · CHUniversity of Kentucky · USUniversity of Minnesota · USUniversity of Veterinary Medicine Hannover, Foundation · DE

Funding

Case Studies In GeneticsZIALM000097 · NLM · NATIONAL LIBRARY OF MEDICINE · PI SCHAFFER, ALEJANDRO A · 2009 to 2019
$4.6M
Intramural NIH HHS Z99 LM999999
6 · The paper itself

Abstract

A comprehensive second-generation whole genome radiation hybrid (RH II), cytogenetic and comparative map of the horse genome (2n = 64) has been developed using the 5000rad horse x hamster radiation hybrid panel and fluorescence in situ hybridization (FISH). The map contains 4,103 markers (3,816 RH; 1,144 FISH) assigned to all 31 pairs of autosomes and the X chromosome. The RH maps of individual chromosomes are anchored and oriented using 857 cytogenetic markers. The overall resolution of the map is one marker per 775 kilobase pairs (kb), which represents a more than five-fold improvement over the first-generation map. The RH II incorporates 920 markers shared jointly with the two recently reported meiotic maps. Consequently the two maps were aligned with the RH II maps of individual autosomes and the X chromosome. Additionally, a comparative map of the horse genome was generated by connecting 1,904 loci on the horse map with genome sequences available for eight diverse vertebrates to highlight regions of evolutionarily conserved syntenies, linkages, and chromosomal breakpoints. The integrated map thus obtained presents the most comprehensive information on the physical and comparative organization of the equine genome and will assist future assemblies of whole genome BAC fingerprint maps and the genome sequence. It will also serve as a tool to identify genes governing health, disease and performance traits in horses and assist us in understanding the evolution of the equine genome in relation to other species.

Indexed as

AnimalsChromosome MappingChromosomes, Artificial, BacterialCytogeneticsGenetic MarkersHorsesIn Situ Hybridization, FluorescenceLod ScorePhysical Chromosome MappingRadiation Hybrid MappingSpecies SpecificityGenetic Markers

Identifiers

PMID18931483
PMCPMC2587302
OpenAlexW2031391277

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.