ArticleProceedings of the National Academy of Sciences of the United States of America2008
Dynamic stabilization of actin filaments.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 72 citations in OpenAlex.
- A truncated isoform of Connexin43 caps actin to organize forward delivery of full-length Connexin43.The Journal of cell biology · 2025Article
- Characterization of Mechanical and Cellular Effects of Rhythmic Vertical Vibrations on Adherent Cell Cultures.Bioengineering (Basel, Switzerland) · 2023Article
- Cofilin Acts as a Booster for Progression of Malignant Tumors Represented by Glioma.Cancer management and research · 2022Review
- Anillin propels myosin-independent constriction of actin rings.Nature communications · 2021Article
- LIM and SH3 protein 1 localizes to the leading edge of protruding lamellipodia and regulates axon development.Molecular biology of the cell · 2020Article
- F-Actin Cytoskeleton Network Self-Organization Through Competition and Cooperation.Annual review of cell and developmental biology · 2020Review
- Catastrophic actin filament bursting by cofilin, Aip1, and coronin.The Journal of biological chemistry · 2020Article
- Triggered disassembly and reassembly of actin networks induces rigidity phase transitions.Soft matter · 2019Article
- Zirconia stimulates ECM-remodeling as a prerequisite to pre-osteoblast adhesion/proliferation by possible interference with cellular anchorage.Journal of materials science. Materials in medicine · 2018Article
- Catastrophic disassembly of actin filaments via Mical-mediated oxidation.Nature communications · 2017Article
- Length regulation of mechanosensitive stereocilia depends on very slow actin dynamics and filament-severing proteins.Nature communications · 2015Article
- Article
- Kinetics of sickle cell biorheology and implications for painful vasoocclusive crisis.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- Thermal memory in self-assembled collagen fibril networks.Biophysical journal · 2013Article
- Disulfide cross-linked antiparallel actin dimer.Biochemistry · 2013Article
- Quantitative analysis of approaches to measure cooperative phosphate release in polymerized actin.Biophysical journal · 2012Article
- Cyclase-associated protein (CAP) acts directly on F-actin to accelerate cofilin-mediated actin severing across the range of physiological pH.The Journal of biological chemistry · 2012Article
- The natural product cucurbitacin E inhibits depolymerization of actin filaments.ACS chemical biology · 2012Article
- The conformational state of actin filaments regulates branching by actin-related protein 2/3 (Arp2/3) complex.The Journal of biological chemistry · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We report here that actin filaments in vitro exist in two populations with significantly different shrinkage rates. Newly polymerized filaments shrink rapidly, primarily from barbed ends, at 1.8/s, but as they age they switch to a stable state that shrinks slowly, primarily from pointed ends, at approximately 0.1/s. This dynamic filament stabilization runs opposite to the classical prediction that actin filaments become more unstable with age as they hydrolyze their bound ATP and release phosphate. Upon cofilin treatment, aged filaments revert to a dynamic state that shows accelerated shrinkage from both ends at a combined rate of 5.9/s. In light of recent electron microscopy studies [Orlova A, et al. (2004) Actin-destabilizing factors disrupt filaments by means of a time reversal of polymerization. Proc Natl Acad Sci USA 101:17664-17668], we propose that dynamic stabilization arises from rearrangement of the filament structure from a relatively disordered state immediately after polymerization to the canonical Holmes helix, a change that is reversed by cofilin binding. Our results suggest that plasticity in the internal structure of the actin filament may play a fundamental role in regulating actin dynamics and may help cells build actin assemblies with vastly different turnover rates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.