ArticleJournal of bacteriology2008
Influence of the Pseudomonas quinolone signal on denitrification in Pseudomonas aeruginosa.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 125 citations in OpenAlex.
- Quorum sensing for carbon-neutral wastewater treatment: Mechanisms, challenges, technological pathways, and future prospects.Environmental science and ecotechnology · 2026Review
- The post-translational adaptor protein SadB modulates the pathogenicity ofJournal of bacteriology · 2026Article
- The histidine kinase NahK regulates denitrification and nitric oxide accumulation through RsmA inJournal of bacteriology · 2025Article
- Cyanuric acid in Paramecium secretions is an efficient quorum sensing inducer.The ISME journal · 2025Article
- Negative regulation of biofilm formation by nitric oxide sensing proteins.Biochemical Society transactions · 2023Review
- Pyochelin biotransformation by Staphylococcus aureus shapes bacterial competition with Pseudomonas aeruginosa in polymicrobial infections.Cell reports · 2023Article
- Article
- Molecular Mechanisms and Applications of N-Acyl Homoserine Lactone-Mediated Quorum Sensing in Bacteria.Molecules (Basel, Switzerland) · 2022Review
- Mechanisms of chlorate toxicity and resistance in Pseudomonas aeruginosa.Molecular microbiology · 2022Article
- Exploring the Function of Quorum Sensing Regulated Biofilms in Biological Wastewater Treatment: A Review.International journal of molecular sciences · 2022Review
- A Single Shot of Vesicles.Microbes and environments · 2022Article
- A Commensal Streptococcus Dysregulates theFrontiers in cellular and infection microbiology · 2022Article
- Antimicrobial Weapons of Pseudomonas aeruginosa.Advances in experimental medicine and biology · 2022Article
- Biological and clinical significance of quorum sensing alkylquinolones: current analytical and bioanalytical methods for their quantification.Analytical and bioanalytical chemistry · 2021Review
- Regulation of las and rhl Quorum Sensing on Aerobic Denitrification in Pseudomonas aeruginosa PAO1.Current microbiology · 2021Article
- Mapping of the Denitrification Pathway in Burkholderia thailandensis by Genome-Wide Mutant Profiling.Journal of bacteriology · 2020Article
- Quorum sensing systems regulate heterotrophic nitrification-aerobic denitrification by changing the activity of nitrogen-cycling enzymes.Environmental science and ecotechnology · 2020Article
- Transcriptome analysis reveals that the RNA polymerase-binding protein DksA1 has pleiotropic functions inThe Journal of biological chemistry · 2020Article
- The aerobic respiratory chain of Pseudomonas aeruginosa cultured in artificial urine media: Role of NQR and terminal oxidases.PloS one · 2020Article
- Anaerobiosis influences virulence properties of Pseudomonas aeruginosa cystic fibrosis isolates and the interaction with Staphylococcus aureus.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Denitrification is a well-studied respiratory system that is also important in the biogeochemical nitrogen cycle. Environmental signals such as oxygen and N-oxides have been demonstrated to regulate denitrification, though how denitrification is regulated in a bacterial community remains obscure. Pseudomonas aeruginosa is a ubiquitous bacterium that controls numerous genes through cell-to-cell signals. The bacterium possesses at least two N-acyl-L-homoserine lactone (AHL) signals. In our previous study, these quorum-sensing signals controlled denitrification in P. aeruginosa. In addition to the AHL signals, a third cell-to-cell communication signal, 2-heptyl-3-hydroxy-4-quinolone, referred to as the Pseudomonas quinolone signal (PQS), has been characterized. In this study, we examined the effect of PQS on denitrification to obtain more insight into the respiratory regulation in a bacterial community. Denitrification in P. aeruginosa was repressed by PQS, which was partially mediated by PqsR and PqsE. Measuring the denitrifying enzyme activities indicated that nitrite reductase activity was increased by PQS, whereas PQS inhibited nitric oxide reductase and the nitrate-respiratory chain activities. This is the first report to demonstrate that PQS influences enzyme activities, suggesting this effect is not specific to P. aeruginosa. Furthermore, when iron was supplied to the PQS-added medium, denitrifying activity was almost restored, indicating that the iron chelating property of PQS affected denitrification. Thus, our data indicate that PQS regulates denitrification primarily through iron chelation. The PQS effect on denitrification was relevant in a condition where oxygen was limited and denitrification was induced, suggesting its role in controlling denitrification where oxygen is present.
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