ArticleJournal of bacteriology2008
Regulation of fructose transport and its effect on fructose toxicity in Anabaena spp.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Identification of hypertension-associated bacterial key genes as potential targets and therapeutic agents through integrated bioinformatics approach.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Heterotrophy among Cyanobacteria.ACS omega · 2023Review
- Process Technologies of Cyanobacteria.Advances in biochemical engineering/biotechnology · 2023Article
- Cross-Activation of Two Nitrogenase Gene Clusters by CnfR1 or CnfR2 in the Cyanobacterium Anabaena variabilis.Microbiology spectrum · 2021Article
- Comparative genomic insights into culturable symbiotic cyanobacteria from the water fernMicrobial genomics · 2021Article
- Symbioses of Cyanobacteria in Marine Environments: Ecological Insights and Biotechnological Perspectives.Marine drugs · 2021Review
- Article
- Heat Acclimation of Bifidobacterium longum and Proteomic Changes Behind It.Probiotics and antimicrobial proteins · 2017Article
- Specific Glucoside Transporters Influence Septal Structure and Function in the Filamentous, Heterocyst-Forming Cyanobacterium Anabaena sp. Strain PCC 7120.Journal of bacteriology · 2017Article
- Role of the nifB1 and nifB2 Promoters in Cell-Type-Specific Expression of Two Mo Nitrogenases in the Cyanobacterium Anabaena variabilis ATCC 29413.Journal of bacteriology · 2017Article
- Role of RNA secondary structure and processing in stability of the nifH1 transcript in the cyanobacterium Anabaena variabilis.Journal of bacteriology · 2015Article
- Regulation of Three Nitrogenase Gene Clusters in the Cyanobacterium Anabaena variabilis ATCC 29413.Life (Basel, Switzerland) · 2014Review
- Regulation of nitrogenase gene expression by transcript stability in the cyanobacterium Anabaena variabilis.Journal of bacteriology · 2014Article
- Complete genome sequence of Anabaena variabilis ATCC 29413.Standards in genomic sciences · 2014Article
- Cell-specific gene expression in Anabaena variabilis grown phototrophically, mixotrophically, and heterotrophically.BMC genomics · 2013Article
- Prochlorococcus can use the Pro1404 transporter to take up glucose at nanomolar concentrations in the Atlantic Ocean.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- A Nostoc punctiforme sugar transporter necessary to establish a Cyanobacterium-plant symbiosis.Plant physiology · 2013Article
- Engineering Synechococcus elongatus PCC 7942 for continuous growth under diurnal conditions.Applied and environmental microbiology · 2013Article
- Diverse roles of the GlcP glucose permease in free-living and symbiotic cyanobacteria.Plant signaling & behavior · 2013Article
- Chemoheterotrophic growth of the Cyanobacterium Anabaena sp. strain PCC 7120 dependent on a functional cytochrome c oxidase.Journal of bacteriology · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anabaena variabilis grows heterotrophically using fructose, while the close relative Anabaena sp. strain PCC 7120 does not. Introduction of a cluster of genes encoding a putative ABC transporter, herein named frtRABC, into Anabaena sp. strain PCC 7120 on a replicating plasmid allowed that strain to grow in the dark using fructose, indicating that these genes are necessary and sufficient for heterotrophic growth. FrtR, a putative LacI-like regulatory protein, was essential for heterotrophic growth of both cyanobacterial strains. Transcriptional analysis revealed that the transport system was induced by fructose and that in the absence of FrtR, frtA was very highly expressed, with or without fructose. In the frtR mutant, fructose uptake was immediate, in contrast to that in the wild-type strain, which required about 40 min for induction of transport. In the frtR mutant, high-level expression of the fructose transporter resulted in cells that were extremely sensitive to fructose. Even in the presence of the inducer, fructose, expression of frtA was low in the wild-type strain compared to that in the frtR mutant, indicating that FrtR repressed the transporter genes even in the presence of fructose. FrtR bound to the upstream region of frtA, but binding was not visibly altered by fructose, further supporting the hypothesis that fructose has only a modest effect in relieving repression of frtA by FrtR. A. variabilis grew better with increasing concentrations of fructose up to 50 mM, showing increased cell size and heterocyst frequency. Anabaena sp. strain PCC 7120 did not show any of these changes when it was grown with fructose. Thus, although Anabaena sp. strain PCC 7120 could take up fructose and use it in the dark, fructose did not improve growth in the light.
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