ArticleJournal of bacteriology2008
Posttranscriptional regulation of flagellin synthesis in Helicobacter pylori by the RpoN chaperone HP0958.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Role of a Stem-Loop Structure inInfection and immunity · 2019Article
- Crystal structure of the MSMEG_4306 gene product from Mycobacterium smegmatis.Acta crystallographica. Section F, Structural biology communications · 2018Article
- Hypothetical protein CT398 (CdsZ) interacts with σ(54) (RpoN)-holoenzyme and the type III secretion export apparatus in Chlamydia trachomatis.Protein science : a publication of the Protein Society · 2015Article
- Themes and Variations: Regulation of RpoN-Dependent Flagellar Genes across Diverse Bacterial Species.Scientifica · 2014Review
- Article
- Insertion mutations in Helicobacter pylori flhA reveal strain differences in RpoN-dependent gene expression.Microbiology (Reading, England) · 2013Article
- Transcriptome complexity and riboregulation in the human pathogen Helicobacter pylori.Frontiers in cellular and infection microbiology · 2012Review
- The zinc-ribbon domain of Helicobacter pylori HP0958: requirement for RpoN accumulation and possible roles of homologs in other bacteria.Microbial informatics and experimentation · 2011Article
- Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction.PloS one · 2011Article
- Ulcerogenic Helicobacter pylori strains isolated from children: a contribution to get insight into the virulence of the bacteria.PloS one · 2011Article
- Genetic and molecular characterization of flagellar assembly in Shewanella oneidensis.PloS one · 2011Article
- Motility and chemotaxis in Campylobacter and Helicobacter .Annual review of microbiology · 2011Review
- The chaperone ClpX stimulates expression of Staphylococcus aureus protein A by Rot dependent and independent pathways.PloS one · 2010Article
- Structure of the cytoplasmic domain of the flagellar secretion apparatus component FlhA from Helicobacter pylori.The Journal of biological chemistry · 2010Article
- Built shallow to maintain homeostasis and persistent infection: insight into the transcriptional regulatory network of the gastric human pathogen Helicobacter pylori.PLoS pathogens · 2010Review
- The HP0256 gene product is involved in motility and cell envelope architecture of Helicobacter pylori.BMC microbiology · 2010Article
- Effect of FliK mutation on the transcriptional activity of the {sigma}54 sigma factor RpoN in Helicobacter pylori.Microbiology (Reading, England) · 2009Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The Helicobacter pylori protein HP0958 is essential for flagellum biogenesis. It has been shown that HP0958 stabilizes the sigma(54) factor RpoN. The aim of this study was to further investigate the role of HP0958 in flagellum production in H. pylori. Global transcript analysis identified a number of flagellar genes that were differentially expressed in an HP0958 mutant strain. Among these, the transcription of the major flagellin gene flaA was upregulated twofold, suggesting that HP0958 was a negative regulator of the flaA gene. However, the production of the FlaA protein was significantly reduced in the HP0958 mutant, and this was not due to the decreased stability of the FlaA protein. RNA stability analysis and binding assays indicated that HP0958 binds and destabilizes flaA mRNA. The HP0958 mutant was successfully complemented, confirming that the mutant phenotype described was due to the lack of HP0958. We conclude that HP0958 is a posttranscriptional regulator that modulates the amount of the flaA message available for translation in H. pylori.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.