Evidence map›Paper›PMID 18931062›Full record

ArticleThe Journal of general virology2008

The origin and phylogeography of dog rabies virus.

Hervé Bourhy, Jean-Marc Reynes, Eleca J Dunham, Laurent Dacheux, Florence Larrous, Vu Thi Que Huong, Gelin Xu, Jiaxin Yan, Mary Elizabeth G Miranda, Edward C Holmes

Abstract read
In one paragraph

Article in The Journal of general virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 255 citations in OpenAlex.

  1. Review
  2. Arctic-like lineage of rabies virus detected in Indian wild fox: a case study.Veterinary research forum : an international quarterly journal · 2026
    Article
  3. Review
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  16. The Raccoon (Animals : an open access journal from MDPI · 2023
    Review
  17. Article
  18. Pseudotyped Viruses for Lyssavirus.Advances in experimental medicine and biology · 2023
    Article
  19. Article
  20. Article

50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 6 countries.

Hervé BourhyInstitut Pasteur, UPRE Lyssavirus Dynamics and Host Adaptation, World Health Organization Collaborating Centre for Reference and Research on Rabies, Institut Pasteur, 75724 Paris Cedex 15, France.
Jean-Marc ReynesInstitut Pasteur of Cambodia, Phnom Penh, Cambodia.
Eleca J DunhamCenter for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, PA 16802, USA.
Laurent DacheuxInstitut Pasteur, UPRE Lyssavirus Dynamics and Host Adaptation, World Health Organization Collaborating Centre for Reference and Research on Rabies, Institut Pasteur, 75724 Paris Cedex 15, France.
Florence LarrousInstitut Pasteur, UPRE Lyssavirus Dynamics and Host Adaptation, World Health Organization Collaborating Centre for Reference and Research on Rabies, Institut Pasteur, 75724 Paris Cedex 15, France.
Vu Thi Que HuongInstitut Pasteur of Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Gelin XuWuhan Institute of Biological Products, Wuhan, Hubei Province 430060, PR China.
Jiaxin YanWuhan Institute of Biological Products, Wuhan, Hubei Province 430060, PR China.
Mary Elizabeth G MirandaVeterinary Research Department, Research Institute for Tropical Medicine, Ficc Alabang, Muntinlupa City 1781, Metro Manila, Philippines.
Edward C HolmesFogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA.
Institut Pasteur · FRWuhan Institute of Bioengineering · CNCenter for Disease Dynamics, Economics & Policy · USInstitut Pasteur du Cambodge · KHInstitut Pasteur in Ho Chi Minh City · VNNational Institutes of Health · USResearch Institute for Tropical Medicine · PH

Funding

The Evolutionary and Biological Bases of Host Switching in VirusesR01GM080533 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PARRISH, COLIN R. · 2007 to 2019
$4.1M
NIGMS NIH HHS GM080533-01NIGMS NIH HHS R01 GM080533
6 · The paper itself

Abstract

Rabies is a progressively fatal and incurable viral encephalitis caused by a lyssavirus infection. Almost all of the 55 000 annual rabies deaths in humans result from infection with dog rabies viruses (RABV). Despite the importance of rabies for human health, little is known about the spread of RABV in dog populations, and patterns of biodiversity have only been studied in limited geographical space. To address these questions on a global scale, we sequenced 62 new isolates and performed an extensive comparative analysis of RABV gene sequence data, representing 192 isolates sampled from 55 countries. From this, we identified six clades of RABV in non-flying mammals, each of which has a distinct geographical distribution, most likely reflecting major physical barriers to gene flow. Indeed, a detailed analysis of phylogeographic structure revealed only limited viral movement among geographical localities. Using Bayesian coalescent methods we also reveal that the sampled lineages of canid RABV derive from a common ancestor that originated within the past 1500 years. Additionally, we found no evidence for either positive selection or widespread population bottlenecks during the global expansion of canid RABV. Overall, our study reveals that the stochastic processes of genetic drift and population subdivision are the most important factors shaping the global phylogeography of canid RABV.

Indexed as

AnimalsBase SequenceBiological EvolutionDog DiseasesDogsGenes, ViralGeographyHumansLyssavirusMolecular Sequence DataNucleocapsid ProteinsPhylogenyRabiesRabies virusNucleocapsid Proteins

Identifiers

PMID18931062
PMCPMC3326349
OpenAlexW2098247212

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.