ArticleAmerican journal of physiology. Lung cellular and molecular physiology2009
Alcohol feeding blocks methacholine-induced airway responsiveness in mice.
Article in American journal of physiology. Lung cellular and molecular physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Chronic + binge alcohol exposure promotes inflammation and alters airway mechanics in the lung.Alcohol (Fayetteville, N.Y.) · 2019Article
- Plp1 gene duplication inhibits airway responsiveness and induces lung inflammation.Pulmonary pharmacology & therapeutics · 2015Article
- Ethanol-induced alcohol dehydrogenase E (AdhE) potentiates pneumolysin in Streptococcus pneumoniae.Infection and immunity · 2015Article
- Treatment with the C5a receptor/CD88 antagonist PMX205 reduces inflammation in a murine model of allergic asthma.International immunopharmacology · 2014Article
- Adenylate kinase from Streptococcus pneumoniae is essential for growth through its catalytic activity.FEBS open bio · 2014Article
- Chronic alcohol induces M2 polarization enhancing pulmonary disease caused by exposure to particulate air pollution.Alcoholism, clinical and experimental research · 2013Article
- Chemokines mediate ethanol-induced exacerbations of murine cockroach allergen asthma.Clinical and experimental immunology · 2013Article
- Nebulization with γ-tocopherol ameliorates acute lung injury after burn and smoke inhalation in the ovine model.Shock (Augusta, Ga.) · 2012Article
- Alcohol reduces airway hyperresponsiveness (AHR) and allergic airway inflammation in mice.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Toll-like receptor 2 regulates organic dust-induced airway inflammation.American journal of respiratory cell and molecular biology · 2011Article
- Ethanol attenuates contraction of primary cultured rat airway smooth muscle cells.American journal of respiratory cell and molecular biology · 2010Article
- Assessing pulmonary pathology by detailed examination of respiratory function.The American journal of pathology · 2010Article
- Prenatal allergen and diesel exhaust exposure and their effects on allergy in adult offspring mice.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2010Article
- Intranasal organic dust exposure-induced airway adaptation response marked by persistent lung inflammation and pathology in mice.American journal of physiology. Lung cellular and molecular physiology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Historical accounts of alcohol administration to patients with breathing problems suggest that alcohol may have bronchodilating properties. We hypothesized that acute alcohol exposure will alter airway responsiveness (AR) in mice. To test this hypothesis, C57BL/6 mice were fed either 20% alcohol in drinking water (fed) or received a single intraperitoneal (ip) injection of alcohol (3 g/kg). Control groups received regular drinking water or ip saline. AR was assessed by means of ventilation or barometric plethysmography and reported as either total lung resistance or enhanced pause for each group of mice. To confirm alcohol exposure, elevated blood alcohol levels were documented. Alcohol feeding significantly blocked methacholine-triggered AR compared with water-fed controls. Comparable blunting of AR was also accomplished through a single ip injection of alcohol when compared with saline-injected controls. The alcohol response was slowly reversible in both routes of administration after withdrawal of alcohol: AR attenuation by alcohol persisted 12-20 h (ip) or up to 2 wk (fed) after blood alcohol cleared consistent with a sustained bronchodilator effect. These data demonstrate that brief alcohol exposure blunts AR in this murine model of alcohol exposure suggesting a role for alcohol in the modulation of bronchial motor tone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.