ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2009
Inflammation and oxidative stress in vertebrate host-parasite systems.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
118 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- On the diverse and opposing effects of nutrition on pathogen virulence.Proceedings. Biological sciences · 2019Pooled it
- Relevance of Trypanothione Reductase Inhibitors onOxidative medicine and cellular longevity · 2018Pooled it
- A cluster-randomized trial of water, sanitation, handwashing and nutritional interventions on stress and epigenetic programming.Nature communications · 2024Trial
- Oxidative Stress and Inflammatory Responses in Horses Naturally Infected withPharmaceuticals (Basel, Switzerland) · 2026Article
- Developmental and geographic transcriptomic variation in Anisakis simplex (s. s.) reveals lncRNA-mediated regulation of mRNA expression.Scientific reports · 2026Article
- Imaging mass cytometry of the immune microenvironment in alveolar echinococcosis.Frontiers in cellular and infection microbiology · 2026Article
- Dynamics of resting metabolic rate and innate immune response in malaria-infected Eurasian siskins.Current zoology · 2025Article
- LC-MS Evaluation of the Redox Trypanothione Balance inAntioxidants (Basel, Switzerland) · 2025Article
- The epidemiology of a novelInternational journal for parasitology. Parasites and wildlife · 2025Article
- An immune challenge affects growth dynamics, oxidative stress and survival in wild spotless starling nestlings.The Journal of experimental biology · 2025Article
- Defence Warriors: Exploring the crosstalk between polyamines and oxidative stress during microbial pathogenesis.Redox biology · 2025Review
- Assessment of Oxidative Stress and Associated Biomarkers in Wild Avian Species.Animals : an open access journal from MDPI · 2025Review
- Nematode serine protease inhibitor SPI-I8 negatively regulates host NF-κB signalling by hijacking MKRN1-mediated polyubiquitination of RACK1.Communications biology · 2025Article
- A high-lipid diet leads to greater pathology and lower tolerance during infection.The Journal of experimental biology · 2025Article
- The Promise of a Pointillist Perspective for Comparative Immunology.Physiology (Bethesda, Md.) · 2024Review
- The Impact of HIV and Parasite Single Infection and Coinfection on Telomere Length: A Systematic Review.Current issues in molecular biology · 2024Review
- Correlated evolution of oxidative physiology and MHC-based immunosurveillance in birds.Proceedings. Biological sciences · 2024Article
- Targeting Trypanothione Metabolism in Trypanosomatids.Molecules (Basel, Switzerland) · 2024Review
- Green Synthesis of Gold Nanoparticles Using Liquiritin and Other Phenolics fromJournal of functional biomaterials · 2024Article
- ROS are required for the germinative cell proliferation and metacestode larval growth ofFrontiers in microbiology · 2024Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Innate, inflammation-based immunity is the first line of vertebrate defence against micro-organisms. Inflammation relies on a number of cellular and molecular effectors that can strike invading pathogens very shortly after the encounter between inflammatory cells and the intruder, but in a non-specific way. Owing to this non-specific response, inflammation can generate substantial costs for the host if the inflammatory response, and the associated oxygen-based damage, get out of control. This imposes strong selection pressure that acts to optimize two key features of the inflammatory response: the timing of activation and resolution (the process of downregulation of the response). In this paper, we review the benefits and costs of inflammation-driven immunity. Our aim is to emphasize the importance of resolution of inflammation as a way of maintaining homeostasis against oxidative stress and to prevent the 'horror autotoxicus' of chronic inflammation. Nevertheless, host immune regulation also opens the way to pathogens to subvert host defences. Therefore, quantifying inflammatory costs requires assessing (i) short-term negative effects, (ii) delayed inflammation-driven diseases, and (iii) parasitic strategies to subvert inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.