ReviewTrends in pharmacological sciences2008
Regulation of calcium-sensing-receptor trafficking and cell-surface expression by GPCRs and RAMPs.
Review in Trends in pharmacological sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Molecular regulation of calcium-sensing receptor (CaSR)-mediated signaling.Chronic diseases and translational medicine · 2024Review
- Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins.Pharmacological reviews · 2023Review
- Extracellular calcium alters calcium-sensing receptor network integrating intracellular calcium-signaling and related key pathway.Scientific reports · 2021Article
- Halofuginone, a promising drug for treatment of pulmonary hypertension.British journal of pharmacology · 2021Article
- Multiplexed analysis of the secretin-like GPCR-RAMP interactome.Science advances · 2019Article
- Functional Analysis and Immunochemical Analyses of CaExperimental neurobiology · 2018Article
- Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- RAMP1 is a direct NKX3.1 target gene up-regulated in prostate cancer that promotes tumorigenesis.The American journal of pathology · 2013Article
- Primary hyperparathyroidism in a patient with familial hypocalciuric hypercalcaemia due to a novel mutation in the calcium-sensing receptor gene.Journal of bone and mineral metabolism · 2013Article
- Regulation of post-Golgi traffic of G protein-coupled receptors.Sub-cellular biochemistry · 2012Review
- Small GTPase regulation of GPCR anterograde trafficking.Trends in pharmacological sciences · 2012Review
- Interaction of actin with carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) receptor in liposomes is Ca2+- and phospholipid-dependent.The Journal of biological chemistry · 2011Article
- Analysis of metabotropic glutamate receptor 7 as a potential substrate for SUMOylation.Neuroscience letters · 2011Article
- Calmodulin regulates Ca2+-sensing receptor-mediated Ca2+ signaling and its cell surface expression.The Journal of biological chemistry · 2010Article
- Mechanisms of multimodal sensing by extracellular Ca(2+)-sensing receptors: a domain-based survey of requirements for binding and signalling.British journal of pharmacology · 2010Review
- Activation of calcitonin receptor and calcitonin receptor-like receptor by membrane-anchored ligands.The Journal of biological chemistry · 2010Article
- Presynaptic external calcium signaling involves the calcium-sensing receptor in neocortical nerve terminals.PloS one · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The calcium-sensing (CaS) receptor is a G-protein-coupled receptor (GPCR) that is of fundamental importance for extracellular calcium signalling and calcium homeostasis. The CaS receptor detects changes in free, ionized extracellular calcium concentration and initiates pathways that constantly re-adjust levels of circulating calcium. In addition, the CaS receptor is involved in processes such as stem-cell homing and regulation of neuronal-process outgrowth. To perform these functions, the CaS receptor must be appropriately targeted to the plasma membrane so that its large N-terminal calcium-sensing domain is positioned in the extracellular environment to detect dynamic changes in ionic calcium concentration. Here, we provide an overview of the molecular determinants controlling CaS receptor forward traffic and highlight the roles of CaS receptor interactors such as receptor-activity-modifying proteins and subunits of other class C GPCRs in this process.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.