ReviewProgress in neurobiology2008
Evaluating epigenetic landmarks in the brain of multiple sclerosis patients: a contribution to the current debate on disease pathogenesis.
Review in Progress in neurobiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Reversing inflammatory diseases via trained immunity: mechanisms, challenges, and prospects.Frontiers in immunology · 2025Review
- Vitamin D3 improves spatial memory and modulates cytokine levels in aged rats.Metabolic brain disease · 2023Article
- Newly Identified Deficiencies in the Multiple Sclerosis Central Nervous System and Their Impact on the Remyelination Failure.Biomedicines · 2022Review
- Probiotic supplementation and systemic inflammation in relapsing-remitting multiple sclerosis: A randomized, double-blind, placebo-controlled trial.Frontiers in neuroscience · 2022Article
- Integrative analysis revealed potential causal genetic and epigenetic factors for multiple sclerosis.Journal of neurology · 2019Article
- Trained Innate Immunity Not Always Amicable.International journal of molecular sciences · 2019Review
- Myelin Basic Protein Citrullination in Multiple Sclerosis: A Potential Therapeutic Target for the Pathology.Neurochemical research · 2016Review
- Epigenetic Drugs for Multiple Sclerosis.Current neuropharmacology · 2016Review
- DNA methyltransferase 3a and mitogen-activated protein kinase signaling regulate the expression of fibroblast growth factor-inducible 14 (Fn14) during denervation-induced skeletal muscle atrophy.The Journal of biological chemistry · 2014Article
- Epigenetic Mechanism in Regulation of Endothelial Function by Disturbed Flow: Induction of DNA Hypermethylation by DNMT1.Cellular and molecular bioengineering · 2014Article
- Metabolic memory and chronic diabetes complications: potential role for epigenetic mechanisms.Current diabetes reports · 2012Review
- Increased promoter methylation of the immune regulatory gene SHP-1 in leukocytes of multiple sclerosis subjects.Journal of neuroimmunology · 2012Article
- DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients.The EMBO journal · 2012Article
- Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data.Genome medicine · 2011Article
- Role of histone acetylation in the development of diabetic retinopathy and the metabolic memory phenomenon.Journal of cellular biochemistry · 2010Article
- Defining the chromatin landscape in demyelinating disorders.Neurobiology of disease · 2010Review
- Methylation patterns of cell-free plasma DNA in relapsing-remitting multiple sclerosis.Journal of the neurological sciences · 2010Article
- Review
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The evidence suggesting a role of epigenetics in the definition of complex trait diseases is rapidly increasing. The gender prevalence of multiple sclerosis, the low level concordance in homozygous twins and the linkage to several genetic loci, suggest an epigenetic component to the definition of this demyelinating disorder. While the immune etio-pathogenetic mechanism of disease progression has been well characterized, still relatively little is known about the initial events contributing to onset and progression of the demyelinating lesion. This article addresses the challenging question of whether loss of the mechanisms of epigenetic regulation of gene expression in the myelinating cells may contribute to the pathogenesis of multiple sclerosis, by affecting the repair process and by modulating the levels of enzymes involved in neo-epitope formation. The role of altered post-translational modifications of nucleosomal histones and DNA methylation in white matter oligodendroglial cells are presented in terms of pathogenetic concepts and the relevance to therapeutic intervention is then discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.