Trial reportBrain research2008
Evoked amygdala responses to negative faces revealed by adaptive MEG beamformers.
Trial report in Brain research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06484088 (Characterizing the Brain Circuitry and Neural Activity Mediating Frustration), which is not on this map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Characterizing the Brain Circuitry and Neural Activity Mediating Frustration
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Characterizing hippocampal dynamics with MEG: A systematic review and evidence-based guidelines.Human brain mapping · 2019Pooled it
- Temporal-spatial neural activation patterns linked to perceptual encoding of emotional salience.PloS one · 2014Trial
- Trial
- Synaptic potentiation is critical for rapid antidepressant response to ketamine in treatment-resistant major depression.Biological psychiatry · 2012Trial
- Magnetoencephalography Reveals Neuroprotection of COVID-19 Vaccination in Nonhuman Primates.Vaccines · 2026Article
- Intrinsic Neural Timescales Relate to Event-Related Activity-Key Role for Intracolumnar Connections.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Thalamo-cortical circuits during sensory attenuation in emerging psychosis: a combined magnetoencephalography and dynamic causal modelling study.Schizophrenia (Heidelberg, Germany) · 2023Article
- Neural underpinnings of threat bias in relation to loss-of-control eating behaviors among adolescent girls with high weight.Frontiers in psychiatry · 2023Article
- Article
- The NIMH intramural healthy volunteer dataset: A comprehensive MEG, MRI, and behavioral resource.Scientific data · 2022Article
- MEG source imaging detects optogenetically-induced activity in cortical and subcortical networks.Nature communications · 2021Article
- Basal ganglia activation localized in MEG using a reward task.Neuroimage. Reports · 2021Article
- High gamma cortical processing of continuous speech in younger and older listeners.NeuroImage · 2020Article
- Investigating cortico-subcortical circuits during auditory sensory attenuation: A combined magnetoencephalographic and dynamic causal modeling study.Human brain mapping · 2020Article
- Abnormal alpha band power in the dynamic pain connectome is a marker of chronic pain with a neuropathic component.NeuroImage. Clinical · 2020Article
- Enhanced Early Visual Responses During Implicit Emotional Faces Processing in Autism Spectrum Disorder.Journal of autism and developmental disorders · 2019Article
- Deep brain activities can be detected with magnetoencephalography.Nature communications · 2019Article
- Magnocellular and parvocellular pathway contributions to facial threat cue processing.Social cognitive and affective neuroscience · 2019Article
- Magnetoencephalography: Clinical and Research Practices.Brain sciences · 2018Review
- Mapping the Spatiotemporal Evolution of Emotional Processing: An MEG Study Across Arousal and Valence Dimensions.Frontiers in human neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Adaptive beamformer analyses of magnetoencephalograms (MEG) have shown promise as a method for functional imaging of cortical processes. Although recent evidence is encouraging, it is unclear whether these methods can both localize and reconstruct the time course of activity in subcortical structures such as the amygdala. Fourteen healthy participants (7 women) performed a perceptual matching task of negative emotional faces (angry and fearful) and geometric shapes that was designed for functional magnetic resonance imaging (fMRI) studies to maximize amygdala activation. Neuromagnetic data were collected with a 275-channel whole-head magnetometer, and event-related adaptive beamformer analyses were conducted to estimate broadband evoked responses to faces and shapes across the whole brain in 7 mm steps. Group analyses revealed greater left amygdala activity to faces over shapes, both when face-matching and shape-matching trials were presented in separate blocks and when they were randomly intermixed. This finding was replicated in a second experiment with 7 new participants (3 women). Virtual sensor time series showed clear evoked responses in the left amygdala and left fusiform gyrus in both runs and experiments. We conclude that amygdala activity can be resolved from MEGs with adaptive beamformers with temporal resolution superior to other neuroimaging modalities. This demonstration should encourage the use of MEG for elucidating functional networks mediating fear-related neural phenomena that likely unfold rapidly in time across cortical and subcortical structures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.